3-chloro-N-(trans-4-(propylamino)cyclohexyl)-N-(3-(pyridin-4-yl)benzyl)benzo[b]thiophene-2-carboxamide

Base Information

• Chemical Name: 3-chloro-N-(trans-4-(propylamino)cyclohexyl)-N-(3-(pyridin-4-yl)benzyl)benzo[b]thiophene-2-carboxamide
• CAS No.: 1060978-40-6
• Molecular Formula: C₃₀H₃₂ClN₃OS
• Molecular Weight: 518.123

Synonyms:3-chloro-N-(trans-4-(propylamino)cyclohexyl)-N-(3-(pyridin-4-yl)benzyl)benzo[b]thiophene-2-carboxamide

Chemical Property of 3-chloro-N-(trans-4-(propylamino)cyclohexyl)-N-(3-(pyridin-4-yl)benzyl)benzo[b]thiophene-2-carboxamide

Chemical Property:

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Technology Process of 3-chloro-N-(trans-4-(propylamino)cyclohexyl)-N-(3-(pyridin-4-yl)benzyl)benzo[b]thiophene-2-carboxamide

There total 9 articles about 3-chloro-N-(trans-4-(propylamino)cyclohexyl)-N-(3-(pyridin-4-yl)benzyl)benzo[b]thiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

C32H34ClN3O3S + 1-iodo-propane (107-08-4) → 3-chloro-N-(trans-4-(propylamino)cyclohexyl)-N-(3-(pyridin-4-yl)benzyl)benzo[b]thiophene-2-carboxamide (1060978-40-6)

Guidance literature:

C₃₂H₃₄ClN₃O₃S; With water; In N,N-dimethyl-formamide; for 1h; Cooling with ice;

With sodium hydride; for 1h; Cooling with ice;

1-iodo-propane; at 20 ℃;

DOI:10.1016/j.bmc.2021.116144

Reference yield:

{4-[(3-chloro-benzo[b]thiophene-2-carbonyl)-(3-pyridin-4-yl-benzyl)-amino]-cyclohexyl}-carbamic acid tert-butyl-ester + 1-iodo-propane (107-08-4) → 3-chloro-N-(trans-4-(propylamino)cyclohexyl)-N-(3-(pyridin-4-yl)benzyl)benzo[b]thiophene-2-carboxamide (1060978-40-6)

Guidance literature:

With trifluoroacetic acid;

Reference yield:

C35H40ClN3O3S (1060978-35-9) → 3-chloro-N-(trans-4-(propylamino)cyclohexyl)-N-(3-(pyridin-4-yl)benzyl)benzo[b]thiophene-2-carboxamide (1060978-40-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.3762/bjoc.8.94

upstream raw materials:

1-iodo-propane

C₂₃H₃₁N₃O₂

C₂₆H₃₇N₃O₂

C₃₅H₄₀ClN₃O₃S

Downstream raw materials:

C₃₆H₃₅ClN₄O₂S

C₃₅H₃₄ClN₃O₂S₂

C₃₈H₃₅ClN₄O₂S

C₃₈H₃₈ClN₃O₃S

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