{[7-chloro-3-(2,5-difluorophenyl)-1,2-benzisoxazol-6-yl]oxy}acetic acid

Base Information

Chemical Name:{[7-chloro-3-(2,5-difluorophenyl)-1,2-benzisoxazol-6-yl]oxy}acetic acid
CAS No.:72482-13-4
Molecular Formula:C₁₅H₈ClF₂NO₄
Molecular Weight:339.683
Hs Code.:

Synonyms:{[7-chloro-3-(2,5-difluorophenyl)-1,2-benzisoxazol-6-yl]oxy}acetic acid

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Chemical Property of {[7-chloro-3-(2,5-difluorophenyl)-1,2-benzisoxazol-6-yl]oxy}acetic acid

Chemical Property:

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Technology Process of {[7-chloro-3-(2,5-difluorophenyl)-1,2-benzisoxazol-6-yl]oxy}acetic acid

There total 10 articles about {[7-chloro-3-(2,5-difluorophenyl)-1,2-benzisoxazol-6-yl]oxy}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 584-08-7
potassium carbonate

: 105-36-2
ethyl bromoacetate

: 72482-12-3
7-chloro-3-(2,5-difluorophenyl)-6-hydroxy-1,2-benzisoxazole

: 72482-13-4
{[7-chloro-3-(2,5-difluorophenyl)-1,2-benzisoxazol-6-yl]oxy}acetic acid

Guidance literature:: With sodium hydroxide; In water; N,N-dimethyl-formamide;

Reference yield:

: [7-Chloro-3-(2,5-difluoro-phenyl)-benzo[d]isoxazol-6-yloxy]-acetic acid ethyl ester

: 72482-13-4
{[7-chloro-3-(2,5-difluorophenyl)-1,2-benzisoxazol-6-yl]oxy}acetic acid

Guidance literature:: With sodium hydroxide; In N,N-dimethyl-formamide; at 90 ℃; for 1.5h; Yield given;
DOI:10.1021/jm00343a008

Reference yield:

: 7051-15-2
2-chlororesorcinol dimethyl ether

: 72482-13-4
{[7-chloro-3-(2,5-difluorophenyl)-1,2-benzisoxazol-6-yl]oxy}acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: AlCl₃ / 1,2-dichloro-ethane / 1.) from 5 deg C to RT, 30 min, 2.) reflux, 30 min

2: hydroxylamine hydrochloride, pyridine / 24 h / Heating

3: 1 h / Heating

4: sodium hydride / dimethylformamide / 0.67 h / 30 °C

5: pyridine hydrochloride / 2 h / 180 °C

6: K₂CO₃ / dimethylformamide / 1.) 60 deg C, 2 h, 2.) from 60 deg C to RT, overnight

7: aq. NaOH / dimethylformamide / 1.5 h / 90 °C

With pyridine; sodium hydroxide; aluminium trichloride; hydroxylamine hydrochloride; pyridine hydrochloride; sodium hydride; potassium carbonate; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00343a008