6-((1,2-dimethyl-1H-imidazol-5-yl)(hydroxy)(1-methyl-1H-1,2,3-triazol-5-yl)methyl)-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinolin-4-carbonitrile

Base Information

Chemical Name:6-((1,2-dimethyl-1H-imidazol-5-yl)(hydroxy)(1-methyl-1H-1,2,3-triazol-5-yl)methyl)-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinolin-4-carbonitrile
CAS No.:1599531-50-6
Molecular Formula:C₂₈H₂₄F₃N₇O₂
Molecular Weight:547.539
Hs Code.:

Synonyms:6-((1,2-dimethyl-1H-imidazol-5-yl)(hydroxy)(1-methyl-1H-1,2,3-triazol-5-yl)methyl)-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinolin-4-carbonitrile

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Chemical Property of 6-((1,2-dimethyl-1H-imidazol-5-yl)(hydroxy)(1-methyl-1H-1,2,3-triazol-5-yl)methyl)-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinolin-4-carbonitrile

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Technology Process of 6-((1,2-dimethyl-1H-imidazol-5-yl)(hydroxy)(1-methyl-1H-1,2,3-triazol-5-yl)methyl)-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinolin-4-carbonitrile

There total 15 articles about 6-((1,2-dimethyl-1H-imidazol-5-yl)(hydroxy)(1-methyl-1H-1,2,3-triazol-5-yl)methyl)-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinolin-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 557-21-1
zinc(II) cyanide

: 1599531-47-1
(4-chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(1,2-dimethyl-1H-imidazol-5-yl)(1-methyl-1H-1,2,3-triazol-5-yl)methanol

: 1599531-50-6
6-((1,2-dimethyl-1H-imidazol-5-yl)(hydroxy)(1-methyl-1H-1,2,3-triazol-5-yl)methyl)-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinolin-4-carbonitrile

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc; XPhos; In N,N-dimethyl acetamide; at 125 ℃; Microwave irradiation; Inert atmosphere;

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 1599531-50-6
6-((1,2-dimethyl-1H-imidazol-5-yl)(hydroxy)(1-methyl-1H-1,2,3-triazol-5-yl)methyl)-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinolin-4-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; pyridine / 6 h / 105 °C

2.1: trichlorophosphate / acetonitrile / 7 h / 80 °C

3.1: toluene / 31 h / 92 - 100 °C

4.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / 4 °C

4.2: 15 h / 20 °C

5.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -77 °C

5.2: 1.16 h / -60 - 0 °C

6.1: zinc; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl acetamide / 125 °C / Microwave irradiation; Inert atmosphere

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; isopropylmagnesium chloride; zinc; XPhos; trichlorophosphate; In tetrahydrofuran; hexane; N,N-dimethyl acetamide; toluene; acetonitrile;

Reference yield:

: 683215-73-8
2-(4-(trifluoromethyl)benzyl)malonic acid

: 1599531-50-6
6-((1,2-dimethyl-1H-imidazol-5-yl)(hydroxy)(1-methyl-1H-1,2,3-triazol-5-yl)methyl)-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinolin-4-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate / 6.66 h / 100 - 110 °C

2.1: toluene / 118 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.02 h / -70 °C

3.2: 0.77 h / 0 °C

4.1: manganese(IV) oxide / 1,4-dioxane / 1.17 h / 20 - 60 °C / Inert atmosphere

5.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -50 - -10 °C

5.2: 1 h / -10 - 20 °C

6.1: zinc; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl acetamide / 125 °C / Microwave irradiation; Inert atmosphere

With manganese(IV) oxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; zinc; XPhos; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; hexane; N,N-dimethyl acetamide; toluene;