N-Cyclohexyl-4-oxo-1,4-dihydroquinoline-3-carboxamide

Base Information

• Chemical Name: N-Cyclohexyl-4-oxo-1,4-dihydroquinoline-3-carboxamide
• CAS No.: 283166-82-5
• Molecular Formula: C₁₆H₁₈N₂O₂
• Molecular Weight: 270.331
• DSSTox Substance ID: DTXSID301215267
• Nikkaji Number: J1.372.337K
• ChEMBL ID: CHEMBL310154
• Mol file: 283166-82-5.mol

Synonyms:TimTec1_001638;Oprea1_715866;CHEMBL310154;DTXSID301215267;HMS1538K10;AKOS009232720;SR-01000483321;SR-01000483321-1;N-Cyclohexyl-1,4-dihydro-4-oxo-3-quinolinecarboxamide;N-Cyclohexyl-4-oxo-1,4-dihydroquinoline-3-carboxamide;283166-82-5

Chemical Property of N-Cyclohexyl-4-oxo-1,4-dihydroquinoline-3-carboxamide

Chemical Property:

• XLogP3: 2.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 270.136827821
• Heavy Atom Count: 20
• Complexity: 424

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CCC(CC1)NC(=O)C2=CNC3=CC=CC=C3C2=O

Technology Process of N-Cyclohexyl-4-oxo-1,4-dihydroquinoline-3-carboxamide

There total 3 articles about N-Cyclohexyl-4-oxo-1,4-dihydroquinoline-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate (52980-28-6) + cyclohexylamine (108-91-8,157973-60-9) → 4-oxo-N'-cyclohexyl-1,4-dihydroquinoline-3-carboxamide (283166-82-5)

Guidance literature:

at 120 ℃; for 24h; Heating;

DOI:10.1021/jm0603466

Reference yield:

diethyl (anilinomethylene)malonate (54535-22-7) → 4-oxo-N'-cyclohexyl-1,4-dihydroquinoline-3-carboxamide (283166-82-5)

Guidance literature:

Multi-step reaction with 2 steps

1: diphenylether / 0.5 h / Reflux

2: diphenylether / 1 h / 210 °C

In diphenylether;

DOI:10.3390/molecules19056651

Reference yield:

aniline (62-53-3) → 4-oxo-N'-cyclohexyl-1,4-dihydroquinoline-3-carboxamide (283166-82-5)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol / 3 h / Reflux

2: diphenylether / 0.5 h / Reflux

3: diphenylether / 1 h / 210 °C

In diphenylether; ethanol;

DOI:10.3390/molecules19056651

upstream raw materials:

ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate

cyclohexylamine

aniline

diethyl (anilinomethylene)malonate