N-(4-(3-chlorophenyl)-5-(2-(trifluoromethyl)phenoxy)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

Base Information

Chemical Name:N-(4-(3-chlorophenyl)-5-(2-(trifluoromethyl)phenoxy)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide
CAS No.:1391979-73-9
Molecular Formula:C₂₆H₂₀ClF₃N₂O₄S₂
Molecular Weight:581.036
Hs Code.:

Synonyms:N-(4-(3-chlorophenyl)-5-(2-(trifluoromethyl)phenoxy)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

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Chemical Property of N-(4-(3-chlorophenyl)-5-(2-(trifluoromethyl)phenoxy)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

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Technology Process of N-(4-(3-chlorophenyl)-5-(2-(trifluoromethyl)phenoxy)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

There total 7 articles about N-(4-(3-chlorophenyl)-5-(2-(trifluoromethyl)phenoxy)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.0%

: 383135-47-5
2-[4-(ethanesulfonyl)phenyl]acetic acid

: 1391980-07-6
4-(3-chlorophenyl)-5-(2-(trifluoromethyl)phenoxy)thiazol-2-amine

: 1391979-73-9
N-(4-(3-chlorophenyl)-5-(2-(trifluoromethyl)phenoxy)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 35 ℃; for 48h;
DOI:10.1016/j.bmc.2015.07.068

Reference yield:

: 1197-55-3
4-aminophenylacetic acid

: 1391979-73-9
N-(4-(3-chlorophenyl)-5-(2-(trifluoromethyl)phenoxy)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.75 h / 0 °C

1.2: 20 - 45 °C

1.3: pH 1

2.1: water; potassium hydroxide / ethanol / 20 h / Reflux

2.2: Cooling with ice

3.1: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

5.1: water; sodium hydroxide / ethanol / 20 °C

5.2: pH 1

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 96 h / 35 °C

With hydrogenchloride; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; sodium hydroxide; sodium nitrite; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: ethyl 2-(4-(ethylthio)phenyl)acetate

: 1391979-73-9
N-(4-(3-chlorophenyl)-5-(2-(trifluoromethyl)phenoxy)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

2.1: water; sodium hydroxide / ethanol / 20 °C

2.2: pH 1

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 96 h / 35 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In ethanol; dichloromethane;