N₂-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N₄-cyclobutyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

Base Information

• Chemical Name: N₂-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N₄-cyclobutyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine
• CAS No.: 1263865-05-9
• Molecular Formula: C₂₇H₂₇ClN₆O
• Molecular Weight: 487.004

Synonyms:N₂-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N₄-cyclobutyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

Chemical Property of N₂-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N₄-cyclobutyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

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Technology Process of N₂-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N₄-cyclobutyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

There total 11 articles about N₂-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N₄-cyclobutyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.6%

4-(4-chloro-1H-imidazol-1-yl)-3-methoxybenzenamine (1235491-93-6) + 2-chloro-N-cyclobutyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine (1263868-32-1) → N2-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N4-cyclobutyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine (1263865-05-9)

Guidance literature:

4-(4-chloro-1H-imidazol-1-yl)-3-methoxybenzenamine; 2-chloro-N-cyclobutyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine; With sulfuric acid; In 1-methyl-pyrrolidin-2-one; at 97 ℃; for 20h;

With sodium hydrogencarbonate; In 1-methyl-pyrrolidin-2-one; water; ethyl acetate; at 20 ℃;

Reference yield:

phenylmagnesium bromide (100-58-3) → N2-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N4-cyclobutyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine (1263865-05-9)

Guidance literature:

Multi-step reaction with 7 steps

1.1: tetrahydrofuran; diethyl ether / 0 °C / Reflux

2.1: formic acid; dihydrogen peroxide / water / 4 h / 20 °C

3.1: 1.75 h / 58 - 130 °C

4.1: ammonia / water / 5 h / Heating; High-pressure flask

5.1: trichlorophosphate / 1 h / 110 °C / Microwave irradiation

6.1: 1-methyl-pyrrolidin-2-one / 3 h / 20 °C

7.1: sulfuric acid / 1-methyl-pyrrolidin-2-one / 20 h / 97 °C

7.2: 20 °C

With formic acid; sulfuric acid; ammonia; dihydrogen peroxide; trichlorophosphate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether; water;

Reference yield:

2-Phenylcyclopentanone (1198-34-1) → N2-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N4-cyclobutyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine (1263865-05-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 1.75 h / 58 - 130 °C

2.1: ammonia / water / 5 h / Heating; High-pressure flask

3.1: trichlorophosphate / 1 h / 110 °C / Microwave irradiation

4.1: 1-methyl-pyrrolidin-2-one / 3 h / 20 °C

5.1: sulfuric acid / 1-methyl-pyrrolidin-2-one / 20 h / 97 °C

5.2: 20 °C

With sulfuric acid; ammonia; trichlorophosphate; In 1-methyl-pyrrolidin-2-one; water;

upstream raw materials:

cyclopentanone

phenylmagnesium bromide

2-chloro-5-nitroanisole

2-Phenylcyclopentanone

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