1,1-dimethylethyl (2S,4S)-2-{4-[6-(3,4-diaminophenyl)-2-naphthalenyl]-1H-imidazol-2-yl}-4-methyl-1-pyrrolidinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl (2S,4S)-2-{4-[6-(3,4-diaminophenyl)-2-naphthalenyl]-1H-imidazol-2-yl}-4-methyl-1-pyrrolidinecarboxylate
CAS No.:1318898-49-5
Molecular Formula:C₂₉H₃₃N₅O₂
Molecular Weight:483.613
Hs Code.:

Synonyms:1,1-dimethylethyl (2S,4S)-2-{4-[6-(3,4-diaminophenyl)-2-naphthalenyl]-1H-imidazol-2-yl}-4-methyl-1-pyrrolidinecarboxylate

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Chemical Property of 1,1-dimethylethyl (2S,4S)-2-{4-[6-(3,4-diaminophenyl)-2-naphthalenyl]-1H-imidazol-2-yl}-4-methyl-1-pyrrolidinecarboxylate

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Technology Process of 1,1-dimethylethyl (2S,4S)-2-{4-[6-(3,4-diaminophenyl)-2-naphthalenyl]-1H-imidazol-2-yl}-4-methyl-1-pyrrolidinecarboxylate

There total 6 articles about 1,1-dimethylethyl (2S,4S)-2-{4-[6-(3,4-diaminophenyl)-2-naphthalenyl]-1H-imidazol-2-yl}-4-methyl-1-pyrrolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.6%

: 851883-08-4
4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzene-1,2-diamine

: 1307310-38-8
1,1-dimethylethyl (2S,4S)-2-[4-(6-bromo-2-naphthalenyl)-1H-imidazol-2-yl]-4-methyl-1-pyrrolidinecarboxylate

: 1318898-49-5
1,1-dimethylethyl (2S,4S)-2-{4-[6-(3,4-diaminophenyl)-2-naphthalenyl]-1H-imidazol-2-yl}-4-methyl-1-pyrrolidinecarboxylate

Guidance literature:: With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 100 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 1590-25-6
1-(6-bromonaphthalen-2-yl)ethanone

: 1318898-49-5
1,1-dimethylethyl (2S,4S)-2-{4-[6-(3,4-diaminophenyl)-2-naphthalenyl]-1H-imidazol-2-yl}-4-methyl-1-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; pyridinium hydrobromide perbromide / 0.17 h

1.2: 4 h

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

2.2: 110 °C / Sealed tube

3.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 1.5 h / 100 °C / Inert atmosphere

With pyridinium hydrobromide perbromide; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; acetonitrile;

Reference yield:

: 5773-80-8
6-bromo-2-naphthoic acid

: 1318898-49-5
1,1-dimethylethyl (2S,4S)-2-{4-[6-(3,4-diaminophenyl)-2-naphthalenyl]-1H-imidazol-2-yl}-4-methyl-1-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 12.08 h / 0 - 20 °C / Inert atmosphere

2.1: pyridine / dichloromethane / 12 h / 20 °C / Inert atmosphere

3.1: tetrahydrofuran / 14 h / 0 - 20 °C

3.2: 0.17 h

4.1: acetic acid; pyridinium hydrobromide perbromide / 0.17 h

4.2: 4 h

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

5.2: 110 °C / Sealed tube

6.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 1.5 h / 100 °C / Inert atmosphere

With pyridine; oxalyl dichloride; pyridinium hydrobromide perbromide; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetonitrile;