3-[(tert-butyldimethylsilyl)oxy]-2-{[4-(trifluoromethoxy)phenoxy]methyl}propan-1-ol

Base Information

Chemical Name:3-[(tert-butyldimethylsilyl)oxy]-2-{[4-(trifluoromethoxy)phenoxy]methyl}propan-1-ol
CAS No.:1263188-72-2
Molecular Formula:C₁₇H₂₇F₃O₄Si
Molecular Weight:380.48
Hs Code.:

Synonyms:3-[(tert-butyldimethylsilyl)oxy]-2-{[4-(trifluoromethoxy)phenoxy]methyl}propan-1-ol

Suppliers and Price of 3-[(tert-butyldimethylsilyl)oxy]-2-{[4-(trifluoromethoxy)phenoxy]methyl}propan-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 3-[(tert-butyldimethylsilyl)oxy]-2-{[4-(trifluoromethoxy)phenoxy]methyl}propan-1-ol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-[(tert-butyldimethylsilyl)oxy]-2-{[4-(trifluoromethoxy)phenoxy]methyl}propan-1-ol

There total 3 articles about 3-[(tert-butyldimethylsilyl)oxy]-2-{[4-(trifluoromethoxy)phenoxy]methyl}propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1263188-71-1
tert-butyldimethyl[(2-{[4-(trifluoromethoxy)phenoxy]methyl}allyl)oxy]silane

: 1263188-72-2
3-[(tert-butyldimethylsilyl)oxy]-2-{[4-(trifluoromethoxy)phenoxy]methyl}propan-1-ol

Guidance literature:: tert-butyldimethyl[(2-{[4-(trifluoromethoxy)phenoxy]methyl}allyl)oxy]silane; With sodium tetrahydroborate; iodine; In tetrahydrofuran; at 0 - 20 ℃; for 16h; Inert atmosphere;

With dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 791131-36-7
tert-butyl((2-(iodomethyl)allyl)oxy)dimethylsilane

: 1263188-72-2
3-[(tert-butyldimethylsilyl)oxy]-2-{[4-(trifluoromethoxy)phenoxy]methyl}propan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / acetone / 50 °C

2.1: iodine; sodium tetrahydroborate / tetrahydrofuran / 17 h / 0 - 20 °C

2.2: 3 h / 0 - 20 °C

With sodium tetrahydroborate; iodine; potassium carbonate; In tetrahydrofuran; acetone;
DOI:10.1016/j.bmcl.2015.07.084

Reference yield:

: 116700-73-3
2-(tert-butyl-dimethyl-silanyloxymethyl)-prop-2-en-1-ol

: 1263188-72-2
3-[(tert-butyldimethylsilyl)oxy]-2-{[4-(trifluoromethoxy)phenoxy]methyl}propan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: iodine; triphenylphosphine; 1H-imidazole / dichloromethane / 6 h / 5 °C

2.1: potassium carbonate / acetone / 50 °C

3.1: iodine; sodium tetrahydroborate / tetrahydrofuran / 17 h / 0 - 20 °C

3.2: 3 h / 0 - 20 °C

With 1H-imidazole; sodium tetrahydroborate; iodine; potassium carbonate; triphenylphosphine; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1016/j.bmcl.2015.07.084