3-(2-bromo-4-nitro-1H-imidazol-1-yl)-2-{[4-(trifluoromethoxy)phenoxy]methyl}propan-1-ol

Base Information

Chemical Name:3-(2-bromo-4-nitro-1H-imidazol-1-yl)-2-{[4-(trifluoromethoxy)phenoxy]methyl}propan-1-ol
CAS No.:1263188-75-5
Molecular Formula:C₁₄H₁₃BrF₃N₃O₅
Molecular Weight:440.174
Hs Code.:

Synonyms:3-(2-bromo-4-nitro-1H-imidazol-1-yl)-2-{[4-(trifluoromethoxy)phenoxy]methyl}propan-1-ol

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Chemical Property of 3-(2-bromo-4-nitro-1H-imidazol-1-yl)-2-{[4-(trifluoromethoxy)phenoxy]methyl}propan-1-ol

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Technology Process of 3-(2-bromo-4-nitro-1H-imidazol-1-yl)-2-{[4-(trifluoromethoxy)phenoxy]methyl}propan-1-ol

There total 3 articles about 3-(2-bromo-4-nitro-1H-imidazol-1-yl)-2-{[4-(trifluoromethoxy)phenoxy]methyl}propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1263188-74-4
2-bromo-1-(3-[(tert-butyldimethylsilyl)oxy]-2-{[4-(trifluoromethoxy)phenoxy]methyl}propyl)-4-nitro-1H-imidazole

: 1263188-75-5
3-(2-bromo-4-nitro-1H-imidazol-1-yl)-2-{[4-(trifluoromethoxy)phenoxy]methyl}propan-1-ol

Guidance literature:: 2-bromo-1-(3-[(tert-butyldimethylsilyl)oxy]-2-{[4-(trifluoromethoxy)phenoxy]methyl}propyl)-4-nitro-1H-imidazole; With hydrogenchloride; In ethanol; at 20 ℃; for 12h;

With ammonia; In methanol; ethanol; Cooling with acetone-dry ice;

Reference yield:

: 1263188-71-1
tert-butyldimethyl[(2-{[4-(trifluoromethoxy)phenoxy]methyl}allyl)oxy]silane

: 1263188-75-5
3-(2-bromo-4-nitro-1H-imidazol-1-yl)-2-{[4-(trifluoromethoxy)phenoxy]methyl}propan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: iodine; sodium tetrahydroborate / tetrahydrofuran / 17 h / 0 - 20 °C

1.2: 3 h / 0 - 20 °C

2.1: iodine; triphenylphosphine; 1H-imidazole / dichloromethane / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 82 - 87 °C

4.1: hydrogenchloride / ethanol; water / 20 °C

With 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; iodine; potassium carbonate; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2015.07.084

Reference yield:

: 1263188-72-2
3-[(tert-butyldimethylsilyl)oxy]-2-{[4-(trifluoromethoxy)phenoxy]methyl}propan-1-ol

: 1263188-75-5
3-(2-bromo-4-nitro-1H-imidazol-1-yl)-2-{[4-(trifluoromethoxy)phenoxy]methyl}propan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: iodine; triphenylphosphine; 1H-imidazole / dichloromethane / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 82 - 87 °C

3: hydrogenchloride / ethanol; water / 20 °C

With 1H-imidazole; hydrogenchloride; iodine; potassium carbonate; triphenylphosphine; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2015.07.084