DL-ORNITHINE DIHYDROCHLORIDE

Base Information

• Chemical Name: DL-ORNITHINE DIHYDROCHLORIDE
• CAS No.: 15160-12-0
• Molecular Formula: C₅H₁₂N₂O₂*2ClH
• Molecular Weight: 205.084
• Mol file: 15160-12-0.mol

Synonyms:DL-Ornithine,dihydrochloride; Ornithine, dihydrochloride, DL- (8CI)

Chemical Property of DL-ORNITHINE DIHYDROCHLORIDE

Chemical Property:

• PSA: 89.34000
• LogP: 2.14180

Purity/Quality:

98.5% ^*data from raw suppliers

DL-ORNITHINE DIHYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

Useful:

Technology Process of DL-ORNITHINE DIHYDROCHLORIDE

There total 3 articles about DL-ORNITHINE DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(R)-methyl 2-acetamido-7-chloroheptanoate → (R)-2,5-diaminopentanoic acid dihydrochloride (1069-31-4,3184-13-2,6211-16-1,15160-12-0,16682-12-5,20724-48-5,22834-83-9,26982-21-8,66837-02-3,99815-05-1,36630-89-4)

Guidance literature:

With hydrogenchloride; In water; for 10h; Reflux;

DOI:10.1039/c5ob01111f

Reference yield: 78.0%

2,5-Bis(methoxycarbonylamino)valeriansaeure-methylester (77300-45-9) → Ornithin-dihydrochlorid (1069-31-4,3184-13-2,6211-16-1,15160-12-0,16682-12-5,20724-48-5,22834-83-9,26982-21-8,66837-02-3,99815-05-1,36630-89-4)

Guidance literature:

With hydrogenchloride; formic acid; In water; at 125 ℃; for 24h;

Reference yield:

methyl 2,5-dibromovalerate (50995-48-7) → Ornithin-dihydrochlorid (1069-31-4,3184-13-2,6211-16-1,15160-12-0,16682-12-5,20724-48-5,22834-83-9,26982-21-8,66837-02-3,99815-05-1,36630-89-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 12 percent / dimethylformamide / 7 h / 100 °C

2: 78 percent / conc. HCl, 100percent HCOOH / H₂O / 24 h / 125 °C

With hydrogenchloride; formic acid; In water; N,N-dimethyl-formamide;

upstream raw materials:

2,5-Bis(methoxycarbonylamino)valeriansaeure-methylester

methyl 2,5-dibromovalerate

Downstream raw materials:

(R)-(+)-3-Amino-2-piperidinon

3-(R)-aminopiperidine dihydrochloride

DPAB-D-Orn (cis)

clavulanic acid

Refernces

• 1、 Effenberger, Franz,Drauz, Karlheinz,Foerster, Siegfried,Mueller, Wolfgang. "Aminosaeuren, I. Darstellung von Aminosaeuren aus Halogencarbonsaeure-alkylestern mit Alkalimetallcyanaten". . p. 173 - 189. Retrieved 2007/10/02.