benzyl (4-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)-2-methylbutan-2-yl)carbamate

Base Information

Chemical Name:benzyl (4-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)-2-methylbutan-2-yl)carbamate
CAS No.:1381764-07-3
Molecular Formula:C₂₇H₃₇N₇O₅
Molecular Weight:539.635
Hs Code.:

benzyl (4-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)-2-methylbutan-2-yl)carbamate

Synonyms:benzyl (4-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)-2-methylbutan-2-yl)carbamate

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Chemical Property of benzyl (4-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)-2-methylbutan-2-yl)carbamate

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Technology Process of benzyl (4-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)-2-methylbutan-2-yl)carbamate

There total 3 articles about benzyl (4-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)-2-methylbutan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 34245-49-3
5'-deoxy-5'-methylamino-2',3'-O,O-(1-methylethylidene)adenosine

: 349546-49-2
(3-hydroxy-1,1-dimethylpropyl)carbamic acid benzylester

: 1381764-07-3
benzyl (4-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)-2-methylbutan-2-yl)carbamate

Guidance literature:: With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃;

Reference yield:

: 54043-71-9
4-methoxy-2,2-dimethyl-4-oxobutanoic acid

: 1381764-07-3
benzyl (4-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)-2-methylbutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; diphenyl phosphoryl azide / 0.75 h / Reflux

1.2: Reflux

2.1: lithium borohydride / tetrahydrofuran / 20 °C

3.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

With lithium borohydride; diphenyl phosphoryl azide; sodium tris(acetoxy)borohydride; triethylamine; In tetrahydrofuran; 1,2-dichloro-ethane;

Reference yield:

: 597-43-3
2,2-dimethylsuccinic acid

: 1381764-07-3
benzyl (4-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)-2-methylbutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / 16 h / 0 - 20 °C

1.2: pH 2

2.1: triethylamine; diphenyl phosphoryl azide / 0.75 h / Reflux

2.2: Reflux

3.1: lithium borohydride / tetrahydrofuran / 20 °C

4.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

With lithium borohydride; sulfuric acid; diphenyl phosphoryl azide; sodium tris(acetoxy)borohydride; triethylamine; In tetrahydrofuran; 1,2-dichloro-ethane;