349546-49-2

Usage

Uses

Used in Pharmaceutical Industry:
(3-hydroxy-1,1-dimethylpropyl)carbamic acid benzylester is used as a medication for the treatment of Alzheimer's disease and dementia. It is utilized for its ability to increase acetylcholine levels in the brain, which helps improve cognitive functions such as memory and thinking. The use of rivastigmine as an acetylcholinesterase inhibitor allows for a more effective management of cognitive decline symptoms associated with these conditions.

Upstream product

• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 42514-50-1 1-hydroxy-3-methylbut-3-ylamine 
• 128182-82-1 3-[Benzyloxycarbonylamino]-3-methylbutanoic acid,methyl ester 
• 597-43-3 2,2-dimethylsuccinic acid 
• 54043-71-9 4-methoxy-2,2-dimethyl-4-oxobutanoic acid 
• 105090-72-0 3-azido-3-methylbutanoic acid 
• 541-47-9 3-Methylbutenoic acid 
• 26939-09-3 2,4,4-trimethyl-5,6-dihydro-1,3(4H)-oxazine 

Downstream Products

• 1123693-96-8 C₁₄H₂₁NO₅S 
• 1226913-81-0 benzyl 4-mercapto-2-methylbutan-2-ylcarbamate 
• 1314079-79-2 C₁₅H₂₃NO₇S₂ 
• 1314079-80-5 C₁₆H₂₅NO₇S₂ 
• 1314079-82-7 C₁₇H₂₇NO₉S₃ 
• 1226913-80-9 Br^(1-)*C₁₈H₃₁N₂O₂S⁽¹⁺⁾ 
• 1226913-83-2 CHO₂^(1-)*C₁₈H₃₁N₂O₄S⁽¹⁺⁾ 
• 1226913-76-3 Br^(1-)*C₁₉H₃₃N₂O₂S⁽¹⁺⁾ 
• 1226913-78-5 CHO₂^(1-)*C₁₉H₃₃N₂O₄S⁽¹⁺⁾ 
• 1314079-84-9 C₁₉H₃₃N₂O₄S⁽¹⁺⁾*Cl^(1-) 
• 1314079-85-0 C₂₁H₃₅NO₇S₂ 
• 187107-78-4 S-3-(benzyloxycarbonylamino)-3-methylbutyl ethanethioate 

Relevant academic research and scientific papers

MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF

Disclosed are compounds, pharmaceutical compositions containing the compounds, and the uses of the compounds and compositions as modulators of histone methyltransferases, and for treating diseases influenced by modulation of histone methyltransferase activity.

Structure stability/activity relationships of sulfone stabilized N,N-dichloroamines

Structure stability/activity relationships (SXR) of a new class of N,N-dichloroamine compounds were explored to improve antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Candida albicans while maintaining aqueous solution stability. This study identified a new class of solution-stable and topical antimicrobial agents. These agents are sulfone-stabilized and possess either a quaternary ammonium or sulfonate appendages as a water solubilizing group. Several unique challenges were confronted in the synthesis of these novel compounds which are highlighted in the discussion.

N,N-Dichloroaminosulfonic acids as novel topical antimicrobial agents

2-Dichloroamino-2-methyl-propane-1-sulfonic acid sodium salt (2a), a stable derivative of endogenous N,N-dichlorotaurine (1), has been identified and is under development as a topical antimicrobial agent. Structure-activity relationships of analogs were explored to achieve optimal antimicrobial activity with minimal mammalian toxicity while maintaining the desired stability. All the analogs synthesized showed antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Candida albicans in the range of 1-128 μg/mL and cytotoxicity against mammalian L929 cells in the range 80-1900 μg/mL.

Synthesis of N-protected 14C-labelled (2E)-5-amino-5-methylhex-2-enoic acid analogues

A novel method of preparing N-protected (2E)-5-amino-5-methylhex-2-enoic acids has been developed based on the synthesis of 3-methyl-3-amino-butanol. The method was used to synthesise 14C-labelled compounds of (1) via synthesis of triethylphosphono[1-14C]acetate.