4-(5-benzamido-1H-indol-1-yl)-5-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate

Base Information

Chemical Name:4-(5-benzamido-1H-indol-1-yl)-5-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate
CAS No.:1309069-15-5
Molecular Formula:C₃₀H₃₀BFN₂O₅
Molecular Weight:528.388
Hs Code.:

Synonyms:4-(5-benzamido-1H-indol-1-yl)-5-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate

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Chemical Property of 4-(5-benzamido-1H-indol-1-yl)-5-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate

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Technology Process of 4-(5-benzamido-1H-indol-1-yl)-5-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate

There total 7 articles about 4-(5-benzamido-1H-indol-1-yl)-5-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1309069-14-4
4-(5-benzamido-1H-indol-1-yl)-2-bromo-5-fluorobenzyl acetate

: 73183-34-3
bis(pinacol)diborane

: 1309069-15-5
4-(5-benzamido-1H-indol-1-yl)-5-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate

Guidance literature:: With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 108 ℃; Inert atmosphere;

Reference yield:

: 1309069-12-2
ethyl 4-(5-amino-1H-indol-1-yl)-2-bromo-5-fluorobenzoate

: 1309069-15-5
4-(5-benzamido-1H-indol-1-yl)-5-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 2 h

2: ethanol; sodium tetrahydroborate / tetrahydrofuran / 0 - 20 °C

3: triethylamine / dichloromethane / 2 h

4: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 108 °C / Inert atmosphere

With sodium tetrahydroborate; ethanol; potassium acetate; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

Reference yield:

: 1309069-11-1
ethyl 4-(5-benzamido-1H-indol-1-yl)-2-bromo-5-fluorobenzoate

: 1309069-15-5
4-(5-benzamido-1H-indol-1-yl)-5-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol; sodium tetrahydroborate / tetrahydrofuran / 0 - 20 °C

2: triethylamine / dichloromethane / 2 h

3: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 108 °C / Inert atmosphere

With sodium tetrahydroborate; ethanol; potassium acetate; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane;