N₂-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-ethynyl)phenoxy-3-nitropyridin-2-amine

Base Information

• Chemical Name: N₂-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-ethynyl)phenoxy-3-nitropyridin-2-amine
• CAS No.: 1191279-74-9
• Molecular Formula: C₂₂H₁₆N₄O₃
• Molecular Weight: 384.394

Synonyms:N₂-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-ethynyl)phenoxy-3-nitropyridin-2-amine

Chemical Property of N₂-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-ethynyl)phenoxy-3-nitropyridin-2-amine

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Technology Process of N₂-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-ethynyl)phenoxy-3-nitropyridin-2-amine

There total 2 articles about N₂-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-ethynyl)phenoxy-3-nitropyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

N-(4'-cyanophenyl)-6-[2'',6''-dimethyl-4''-(3-methylbut-3-ol-1-yn)-phenoxy]-3-nitropyridin-2-amine (1191279-73-8) → N2-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-ethynyl)phenoxy-3-nitropyridin-2-amine (1191279-74-9)

Guidance literature:

With sodium hydroxide; In toluene; for 16h; Reflux;

DOI:10.1016/j.bmcl.2009.07.080

Reference yield:

N2-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-iodo)phenoxy-3-nitropyridin-2-amine (1191279-71-6) → N2-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-ethynyl)phenoxy-3-nitropyridin-2-amine (1191279-74-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; copper(l) iodide / C₄₁H₃₅ClP₂Pd / N,N-dimethyl-formamide / 7 h / 20 °C / Inert atmosphere

2: sodium hydroxide / toluene / 24 h / Inert atmosphere; Reflux

With copper(l) iodide; triethylamine; sodium hydroxide; C₄₁H₃₅ClP₂Pd; In N,N-dimethyl-formamide; toluene;

Reference yield: 61.0%

N2-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-ethynyl)phenoxy-3-nitropyridin-2-amine (1191279-74-9) → N2-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-ethynyl)phenoxypyridin-2,3-diamine (1191279-81-8)

Guidance literature:

With ammonium hydroxide; sodium dithionite; In tetrahydrofuran; water; at 20 ℃; for 3h;

DOI:10.1016/j.bmcl.2009.07.080

upstream raw materials:

N-(4'-cyanophenyl)-6-[2'',6''-dimethyl-4''-(3-methylbut-3-ol-1-yn)-phenoxy]-3-nitropyridin-2-amine

N₂-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-iodo)phenoxy-3-nitropyridin-2-amine

Downstream raw materials:

N₂-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-ethynyl)phenoxypyridin-2,3-diamine

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