2-cyclopropyl-6-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]pyridine succinic acid

Base Information

Chemical Name:2-cyclopropyl-6-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]pyridine succinic acid
CAS No.:1301167-97-4
Molecular Formula:C₄H₆O₄*C₂₅H₂₃FN₄O
Molecular Weight:532.571
Hs Code.:

Synonyms:2-cyclopropyl-6-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]pyridine succinic acid

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Chemical Property of 2-cyclopropyl-6-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]pyridine succinic acid

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Technology Process of 2-cyclopropyl-6-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]pyridine succinic acid

There total 7 articles about 2-cyclopropyl-6-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]pyridine succinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: aq. sodium carbonate

2-bromo-6-[[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]-pyridine.0.75 succinate: 2-bromo-6-[[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]-pyridine.0.75 succinate

aq. ammonium carbonate: aq. ammonium carbonate

: palladium ⁽⁰⁾ tetrakis(triphenylphosphine)

: 411235-57-9
cyclopropylboronic acid

: 1301167-97-4
2-cyclopropyl-6-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]pyridine succinic acid

Guidance literature:: In 1,4-dioxane;

Reference yield:

: 1301167-63-4
4-(3-(4-(benzyloxy)phenyl)-1-(2-fluoroethyl)-1H-pyrazol-4-yl)pyridine

: 1301167-97-4
2-cyclopropyl-6-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]pyridine succinic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 5%-palladium/activated carbon; hydrogen / ethanol / 80 °C / 760.05 Torr

2: di-tert-butyl-diazodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.33 h / 120 °C / Microwave irradiation

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane / 0.25 h / 130 °C / Microwave irradiation

4: methanol

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; di-tert-butyl-diazodicarboxylate; 5%-palladium/activated carbon; hydrogen; sodium carbonate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; 3: Suzuki coupling;
DOI:10.1021/jm200536d

Reference yield:

: 1301167-65-6
4-[1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl]phenol

: 1301167-97-4
2-cyclopropyl-6-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]pyridine succinic acid

Guidance literature:: Multi-step reaction with 3 steps

1: di-tert-butyl-diazodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.33 h / 120 °C / Microwave irradiation

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane / 0.25 h / 130 °C / Microwave irradiation

3: methanol

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; di-tert-butyl-diazodicarboxylate; sodium carbonate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; 2: Suzuki coupling;
DOI:10.1021/jm200536d