Technology Process of ethyl 2-((2-benzoyl-4-oxo-4H-thiochromen-3-yl)methyl)acrylate
There total 3 articles about ethyl 2-((2-benzoyl-4-oxo-4H-thiochromen-3-yl)methyl)acrylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-benzoyl-4H-thiochromen-4-one;
With
zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex;
In
tetrahydrofuran;
at -20 ℃;
for 0.25h;
Inert atmosphere;
With
CuCN*2LiCl2;
In
tetrahydrofuran;
at -40 ℃;
for 0.5h;
Inert atmosphere;
ethyl 2-bromomethyl-2-propenoate;
In
tetrahydrofuran;
at -40 - 25 ℃;
for 1.16667h;
regioselective reaction;
Inert atmosphere;
DOI:10.1021/ja306178q
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex / tetrahydrofuran; diethyl ether / 0.5 h / -40 °C / Inert atmosphere
1.2: 0.5 h / -40 °C / Inert atmosphere
1.3: 4 h / -40 - 0 °C / Inert atmosphere
2.1: zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex / tetrahydrofuran / 0.25 h / -20 °C / Inert atmosphere
2.2: 0.5 h / -40 °C / Inert atmosphere
2.3: 1.17 h / -40 - 25 °C / Inert atmosphere
With
zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex;
In
tetrahydrofuran; diethyl ether;
DOI:10.1021/ja306178q
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex / tetrahydrofuran; diethyl ether / 0.5 h / -40 °C / Inert atmosphere
1.2: 0.5 h / -40 °C / Inert atmosphere
1.3: 4 h / -40 - 0 °C / Inert atmosphere
2.1: zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex / tetrahydrofuran / 0.25 h / -20 °C / Inert atmosphere
2.2: 0.5 h / -40 °C / Inert atmosphere
2.3: 1.17 h / -40 - 25 °C / Inert atmosphere
With
zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex;
In
tetrahydrofuran; diethyl ether;
DOI:10.1021/ja306178q
