N-(4-{1-[2-(2,4-dimethyl-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-methanesulfonamide

Base Information

Chemical Name:N-(4-{1-[2-(2,4-dimethyl-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-methanesulfonamide
CAS No.:1076690-65-7
Molecular Formula:C₂₀H₂₃N₃O₃S
Molecular Weight:385.487
Hs Code.:

Synonyms:N-(4-{1-[2-(2,4-dimethyl-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-methanesulfonamide

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Chemical Property of N-(4-{1-[2-(2,4-dimethyl-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-methanesulfonamide

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Technology Process of N-(4-{1-[2-(2,4-dimethyl-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-methanesulfonamide

There total 4 articles about N-(4-{1-[2-(2,4-dimethyl-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1076690-88-4
N-[4-(4,5-dihydro-1H-pyrazol-3-yl)-phenyl]-methanesulfonamide trifluoroacetate

: 6331-04-0
2,4-dimethylphenylacetic acid

: 1076690-65-7
N-(4-{1-[2-(2,4-dimethyl-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-methanesulfonamide

Guidance literature:: With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 1076690-81-7
3-(4-nitro-phenyl)-4,5-dihydro-pyrazole-1-carboxylic acid tert-butyl ester

: 1076690-65-7
N-(4-{1-[2-(2,4-dimethyl-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 17 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.67 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 1.25 h / 20 °C

4: triethylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

With hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 103753-04-4
3-(4-nitro-phenyl)-4,5-dihydro-1H-pyrazole

: 1076690-65-7
N-(4-{1-[2-(2,4-dimethyl-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: dmap / tetrahydrofuran / 2 h / 80 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 17 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.67 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 1.25 h / 20 °C

5: triethylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

With dmap; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;