(S)-iso-propyl α-hydroxy-α-(2-chlorophenyl)acetate

Base Information

• Chemical Name: (S)-iso-propyl α-hydroxy-α-(2-chlorophenyl)acetate
• CAS No.: 1196988-57-4
• Molecular Formula: C₁₁H₁₃ClO₃
• Molecular Weight: 228.675
• Mol file: 1196988-57-4.mol

Synonyms:(S)-iso-propyl α-hydroxy-α-(2-chlorophenyl)acetate

Chemical Property of (S)-iso-propyl α-hydroxy-α-(2-chlorophenyl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-iso-propyl α-hydroxy-α-(2-chlorophenyl)acetate

There total 7 articles about (S)-iso-propyl α-hydroxy-α-(2-chlorophenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

isopropyl-2-(2-chlorophenyl)-2-oxoacetate (62123-77-7) → (S)-iso-propyl α-hydroxy-α-(2-chlorophenyl)acetate (1196988-57-4)

Guidance literature:

With C₄₉H₇₆N₄O₄; aluminum tri-tert-butoxide; yttrium(III) trifluoromethanesulfonate; In chloroform; isopropyl alcohol; for 120h; enantioselective reaction; Molecular sieve;

DOI:10.1039/c7cc00273d

Reference yield:

2-Chlorobenzeneboronic acid (3900-89-8) + isopropyl glyoxalate (924-53-8) → (S)-iso-propyl α-hydroxy-α-(2-chlorophenyl)acetate (1196988-57-4) + (R)-isopropyl 2-(2-chlorophenyl)-2-hydroxyacetate. (1242001-70-2)

Guidance literature:

2-Chlorobenzeneboronic acid; isopropyl glyoxalate; With chlorobis(cyclooctene)rhodium(I) dimer; C₁₉H₂₃NOS; In 1,4-dioxane; at 20 ℃; for 0.5h; Inert atmosphere;

With potassium hydroxide; In 1,4-dioxane; water; at 40 ℃; for 5h; Overall yield = 77 percent; enantioselective reaction; Inert atmosphere;

DOI:10.1055/s-0037-1610722

Reference yield:

isopropyl-2-(2-chlorophenyl)-2-oxoacetate (62123-77-7) → (S)-iso-propyl α-hydroxy-α-(2-chlorophenyl)acetate (1196988-57-4) + (R)-isopropyl 2-(2-chlorophenyl)-2-hydroxyacetate. (1242001-70-2)

Guidance literature:

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; sodium formate; dodecyltrimethylammonium bromide; (-)-(1S,2S)-N-(2,4,6-triisopropybenzenesulfonyl)-1,2-diphenylethylenediamine; In water; at 28 ℃; for 1.5h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1016/j.tetasy.2009.08.019

upstream raw materials:

isopropyl-2-(2-chlorophenyl)-2-oxoacetate

isopropyl 2-(2-chlorophenyl)-2-hydroxyacetate

o-chlorobenzoylformic acid

ethyl 2-(2-chlorophenyl)-2-oxoacetate