O-[2,3,4-tri-O-benzyl-6-O-(2-azido)acetyl-α-D-galactopyranosyl]-N-benzyloxycarbonyl-L-serine benzyl ester

Base Information

Chemical Name:O-[2,3,4-tri-O-benzyl-6-O-(2-azido)acetyl-α-D-galactopyranosyl]-N-benzyloxycarbonyl-L-serine benzyl ester
CAS No.:1385808-71-8
Molecular Formula:C₄₇H₄₈N₄O₁₁
Molecular Weight:844.918
Hs Code.:

Synonyms:O-[2,3,4-tri-O-benzyl-6-O-(2-azido)acetyl-α-D-galactopyranosyl]-N-benzyloxycarbonyl-L-serine benzyl ester

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Chemical Property of O-[2,3,4-tri-O-benzyl-6-O-(2-azido)acetyl-α-D-galactopyranosyl]-N-benzyloxycarbonyl-L-serine benzyl ester

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Technology Process of O-[2,3,4-tri-O-benzyl-6-O-(2-azido)acetyl-α-D-galactopyranosyl]-N-benzyloxycarbonyl-L-serine benzyl ester

There total 3 articles about O-[2,3,4-tri-O-benzyl-6-O-(2-azido)acetyl-α-D-galactopyranosyl]-N-benzyloxycarbonyl-L-serine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21209-51-8
N-benzyloxycarbonyl-L-serine benzyl ester

: 1385808-26-3
phenyl 6-O-(2-azido)acetyl-2,3,4-tri-O-benzyl-1-thio-β-D-galactopyranoside

: 1385808-69-4
O-[2,3,4-tri-O-benzyl-6-O-(2-azido)acetyl-β-D-galactopyranosyl]-N-benzyloxycarbonyl-L-serine benzyl ester

: 1385808-71-8
O-[2,3,4-tri-O-benzyl-6-O-(2-azido)acetyl-α-D-galactopyranosyl]-N-benzyloxycarbonyl-L-serine benzyl ester

Guidance literature:: N-benzyloxycarbonyl-L-serine benzyl ester; phenyl 6-O-(2-azido)acetyl-2,3,4-tri-O-benzyl-1-thio-β-D-galactopyranoside; With N-iodo-succinimide; In acetonitrile; at -40 ℃; for 0.5h; Molecular sieve;

With trifluorormethanesulfonic acid; In acetonitrile; at -40 ℃; for 2h; optical yield given as %de; Molecular sieve;
DOI:10.1055/s-0031-1290975

Reference yield:

: 819798-14-6
phenyl 2,3,4-tri-O-benzyl-6-O-chloroacetyl-1-thio-β-D-galactopyranoside

: 1385808-69-4
O-[2,3,4-tri-O-benzyl-6-O-(2-azido)acetyl-β-D-galactopyranosyl]-N-benzyloxycarbonyl-L-serine benzyl ester

: 1385808-71-8
O-[2,3,4-tri-O-benzyl-6-O-(2-azido)acetyl-α-D-galactopyranosyl]-N-benzyloxycarbonyl-L-serine benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium azide; potassium iodide / acetone / 24 h / 20 °C

2.1: N-iodo-succinimide / acetonitrile / 0.5 h / -40 °C / Molecular sieve

2.2: 2 h / -40 °C / Molecular sieve

With N-iodo-succinimide; sodium azide; potassium iodide; In acetone; acetonitrile;
DOI:10.1055/s-0031-1290975

Reference yield:

: 38184-12-2,120403-26-1,87470-73-3
phenyl 2,3,4-tri-O-benzyl-1-thio-β-D-galactopyranoside

: 1385808-69-4
O-[2,3,4-tri-O-benzyl-6-O-(2-azido)acetyl-β-D-galactopyranosyl]-N-benzyloxycarbonyl-L-serine benzyl ester

: 1385808-71-8
O-[2,3,4-tri-O-benzyl-6-O-(2-azido)acetyl-α-D-galactopyranosyl]-N-benzyloxycarbonyl-L-serine benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 14 h / 0 - 20 °C

2.1: sodium azide; potassium iodide / acetone / 24 h / 20 °C

3.1: N-iodo-succinimide / acetonitrile / 0.5 h / -40 °C / Molecular sieve

3.2: 2 h / -40 °C / Molecular sieve

With N-iodo-succinimide; sodium azide; triethylamine; potassium iodide; In dichloromethane; acetone; acetonitrile;
DOI:10.1055/s-0031-1290975