Technology Process of Thiocarbonic acid O-((5R,6S,7S,8S,8aS)-6,8-diethyl-5-propyl-octahydro-indolizin-7-yl) ester O-phenyl ester
There total 12 articles about Thiocarbonic acid O-((5R,6S,7S,8S,8aS)-6,8-diethyl-5-propyl-octahydro-indolizin-7-yl) ester O-phenyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: TFA / methanol / 2 h / 20 °C
1.2: 35 percent / MgSO4 / CH2Cl2 / 2 h / 20 °C
2.1: 0.74 g / p-toluenesulfonic acid / benzene / 40 h / 20 °C
3.1: 91 percent / Na2CO3 / ethanol / 6 h / Heating
4.1: PhCH=Ru(PCy3)2Cl2 / CH2Cl2 / 2 h / Heating
5.1: 0.135 g / H2 / Pd/C / methanol; CH2Cl2 / 4 h / 20 °C
6.1: 90 percent / NaBH4 / methanol / 2 h / -78 °C
7.1: 55 percent / pyridine / 24 h / 20 °C
With
pyridine; sodium tetrahydroborate; Grubbs catalyst first generation; hydrogen; sodium carbonate; toluene-4-sulfonic acid; trifluoroacetic acid;
palladium on activated charcoal;
In
methanol; ethanol; dichloromethane; benzene;
DOI:10.1021/ja051452k
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: lithium hexamethyldisilazide / diethyl ether; tetrahydrofuran / 1 h / -78 °C
1.2: 78 percent / tetrahydrofuran; diethyl ether / 1 h / -78 °C
2.1: TFA / methanol / 2 h / 20 °C
2.2: 35 percent / MgSO4 / CH2Cl2 / 2 h / 20 °C
3.1: 0.74 g / p-toluenesulfonic acid / benzene / 40 h / 20 °C
4.1: 91 percent / Na2CO3 / ethanol / 6 h / Heating
5.1: PhCH=Ru(PCy3)2Cl2 / CH2Cl2 / 2 h / Heating
6.1: 0.135 g / H2 / Pd/C / methanol; CH2Cl2 / 4 h / 20 °C
7.1: 90 percent / NaBH4 / methanol / 2 h / -78 °C
8.1: 55 percent / pyridine / 24 h / 20 °C
With
pyridine; sodium tetrahydroborate; Grubbs catalyst first generation; hydrogen; sodium carbonate; toluene-4-sulfonic acid; trifluoroacetic acid; lithium hexamethyldisilazane;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; benzene;
DOI:10.1021/ja051452k
