3-(5-Benzylidene-4-oxo-4,5-dihydro-1,3-thiazol-2-yl)-5-cyano-2,6-dihydroxy-4-phenyl-1,4-dihydropyridine

Base Information

Chemical Name:3-(5-Benzylidene-4-oxo-4,5-dihydro-1,3-thiazol-2-yl)-5-cyano-2,6-dihydroxy-4-phenyl-1,4-dihydropyridine
CAS No.:87947-99-7
Molecular Formula:C₂₂H₁₅N₃O₃S
Molecular Weight:401.445
Hs Code.:

Synonyms:3-(5-Benzylidene-4-oxo-4,5-dihydro-1,3-thiazol-2-yl)-5-cyano-2,6-dihydroxy-4-phenyl-1,4-dihydropyridine

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Chemical Property of 3-(5-Benzylidene-4-oxo-4,5-dihydro-1,3-thiazol-2-yl)-5-cyano-2,6-dihydroxy-4-phenyl-1,4-dihydropyridine

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Technology Process of 3-(5-Benzylidene-4-oxo-4,5-dihydro-1,3-thiazol-2-yl)-5-cyano-2,6-dihydroxy-4-phenyl-1,4-dihydropyridine

There total 3 articles about 3-(5-Benzylidene-4-oxo-4,5-dihydro-1,3-thiazol-2-yl)-5-cyano-2,6-dihydroxy-4-phenyl-1,4-dihydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 87947-98-6
2-(1-Aminocarbonylstyryl)-5-benzylidene-4-oxo-4,5-dihydro-1,3-thiazole

: 105-56-6
ethyl 2-cyanoacetate

: 87947-99-7
3-(5-Benzylidene-4-oxo-4,5-dihydro-1,3-thiazol-2-yl)-5-cyano-2,6-dihydroxy-4-phenyl-1,4-dihydropyridine

Guidance literature:: With piperidine; In ethanol; for 4h; Heating;
DOI:10.1055/s-1983-30494

Reference yield:

: 87947-94-2
2-(4-Hydroxy-thiazol-2-yl)-acetamide

: 87947-99-7
3-(5-Benzylidene-4-oxo-4,5-dihydro-1,3-thiazol-2-yl)-5-cyano-2,6-dihydroxy-4-phenyl-1,4-dihydropyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / piperidine / 1 h

2: 88 percent / piperidine / ethanol / 4 h / Heating

With piperidine; In ethanol;
DOI:10.1055/s-1983-30494

Reference yield:

: 100-52-7
benzaldehyde

: 87947-99-7
3-(5-Benzylidene-4-oxo-4,5-dihydro-1,3-thiazol-2-yl)-5-cyano-2,6-dihydroxy-4-phenyl-1,4-dihydropyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / piperidine / 1 h

2: 88 percent / piperidine / ethanol / 4 h / Heating

With piperidine; In ethanol;
DOI:10.1055/s-1983-30494