2-[5-(2,6-dichlorophenyl)-3-methyl-1,2-oxazol-4-yl]-4-(4-dimethylaminobenzylidene)-1,3-oxazol-5(4H)-one

Base Information

Chemical Name:2-[5-(2,6-dichlorophenyl)-3-methyl-1,2-oxazol-4-yl]-4-(4-dimethylaminobenzylidene)-1,3-oxazol-5(4H)-one
CAS No.:1478925-72-2
Molecular Formula:C₂₂H₁₇Cl₂N₃O₃
Molecular Weight:442.301
Hs Code.:

Synonyms:2-[5-(2,6-dichlorophenyl)-3-methyl-1,2-oxazol-4-yl]-4-(4-dimethylaminobenzylidene)-1,3-oxazol-5(4H)-one

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Chemical Property of 2-[5-(2,6-dichlorophenyl)-3-methyl-1,2-oxazol-4-yl]-4-(4-dimethylaminobenzylidene)-1,3-oxazol-5(4H)-one

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Technology Process of 2-[5-(2,6-dichlorophenyl)-3-methyl-1,2-oxazol-4-yl]-4-(4-dimethylaminobenzylidene)-1,3-oxazol-5(4H)-one

There total 3 articles about 2-[5-(2,6-dichlorophenyl)-3-methyl-1,2-oxazol-4-yl]-4-(4-dimethylaminobenzylidene)-1,3-oxazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1478925-76-6
5-(2,6-dichlorophenyl)3-methyl-1,2-oxazol-4-ylcarbonylaminoacetic acid

: 100-10-7
4-dimethylamino-benzaldehyde

: 1478925-72-2
2-[5-(2,6-dichlorophenyl)-3-methyl-1,2-oxazol-4-yl]-4-(4-dimethylaminobenzylidene)-1,3-oxazol-5(4H)-one

Guidance literature:: With acetic anhydride; triphenylphosphine; In neat (no solvent); at 130 ℃; for 0.3h;
DOI:10.1002/jhet.2600

Reference yield:

: 1478925-79-9
5-(2,6-dichlorophenyl)-3-methyl-1,2-oxazole-4-carboxylic acid chloride

: 1478925-72-2
2-[5-(2,6-dichlorophenyl)-3-methyl-1,2-oxazol-4-yl]-4-(4-dimethylaminobenzylidene)-1,3-oxazol-5(4H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water / 1 h

2: acetic anhydride; sodium acetate / 110 °C

With sodium acetate; acetic anhydride; sodium hydroxide; In water;
DOI:10.1016/j.dyepig.2013.07.001

Reference yield:

: 5-(2,6-dichlorophenyl)-3-methyl-1,2-oxazole-4-carboxylic acid

: 1478925-72-2
2-[5-(2,6-dichlorophenyl)-3-methyl-1,2-oxazol-4-yl]-4-(4-dimethylaminobenzylidene)-1,3-oxazol-5(4H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / acetonitrile / 4 h / Reflux

2: sodium hydroxide / water / 1 h

3: acetic anhydride; sodium acetate / 110 °C

With thionyl chloride; sodium acetate; acetic anhydride; sodium hydroxide; In water; acetonitrile;
DOI:10.1016/j.dyepig.2013.07.001