5-(2,6-dichlorophenyl)3-methyl-1,2-oxazol-4-ylcarbonylaminoacetic acid

Base Information

• Chemical Name: 5-(2,6-dichlorophenyl)3-methyl-1,2-oxazol-4-ylcarbonylaminoacetic acid
• CAS No.: 1478925-76-6
• Molecular Formula: C₁₃H₁₀Cl₂N₂O₄
• Molecular Weight: 329.139

Synonyms:5-(2,6-dichlorophenyl)3-methyl-1,2-oxazol-4-ylcarbonylaminoacetic acid

Chemical Property of 5-(2,6-dichlorophenyl)3-methyl-1,2-oxazol-4-ylcarbonylaminoacetic acid

Chemical Property:

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Technology Process of 5-(2,6-dichlorophenyl)3-methyl-1,2-oxazol-4-ylcarbonylaminoacetic acid

There total 2 articles about 5-(2,6-dichlorophenyl)3-methyl-1,2-oxazol-4-ylcarbonylaminoacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(2,6-dichlorophenyl)-3-methyl-1,2-oxazole-4-carboxylic acid chloride (1478925-79-9) + glycine (56-40-6,18875-39-3,25718-94-9) → 5-(2,6-dichlorophenyl)3-methyl-1,2-oxazol-4-ylcarbonylaminoacetic acid (1478925-76-6)

Guidance literature:

With sodium hydroxide; In water; for 1h;

DOI:10.1016/j.dyepig.2013.07.001

Reference yield:

5-(2,6-dichlorophenyl)-3-methyl-1,2-oxazole-4-carboxylic acid → 5-(2,6-dichlorophenyl)3-methyl-1,2-oxazol-4-ylcarbonylaminoacetic acid (1478925-76-6)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / acetonitrile / 4 h / Reflux

2: sodium hydroxide / water / 1 h

With thionyl chloride; sodium hydroxide; In water; acetonitrile;

DOI:10.1016/j.dyepig.2013.07.001

Reference yield: 92.0%

thiophene-2-carbaldehyde (98-03-3) + 5-(2,6-dichlorophenyl)3-methyl-1,2-oxazol-4-ylcarbonylaminoacetic acid (1478925-76-6) → 2-(5-(2,6-dichlorophenyl)-3-methylisoxazol-4-yl)-4-((thiophen-2-yl)methylene)oxazol-5(4H)-one

Guidance literature:

With acetic anhydride; triphenylphosphine; In neat (no solvent); at 130 ℃; for 0.3h;

DOI:10.1002/jhet.2600

upstream raw materials:

5-(2,6-dichlorophenyl)-3-methyl-1,2-oxazole-4-carboxylic acid chloride

glycine

Downstream raw materials:

2-[5-(2,6-dichlorophenyl)-3-methyl-1,2-oxazol-4-yl]-4-benzylidene-1,3-oxazol-5(4H)-one

2-[5-(2,6-dichlorophenyl)-3-methyl-1,2-oxazol-4-yl]-4-(4-chlorobenzylidene)-1,3-oxazol-5(4H)-one

2-[5-(2,6-dichlorophenyl)-3-methyl-1,2-oxazol-4-yl]-4-(4-methoxybenzylidene)-1,3-oxazol-5(4H)-one

2-[5-(2,6-dichlorophenyl)-3-methyl-1,2-oxazol-4-yl]-4-(4-dimethylaminobenzylidene)-1,3-oxazol-5(4H)-one

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