tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}-carbamate

Base Information

Chemical Name:tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}-carbamate
CAS No.:853069-26-8
Molecular Formula:C₂₇H₃₀ClN₅O₃
Molecular Weight:508.02
Hs Code.:

Synonyms:tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}-carbamate

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Chemical Property of tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}-carbamate

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Technology Process of tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}-carbamate

There total 8 articles about tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1349877-43-5
ethyl 2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1-(2-chlorobenzyl)-4-(2-nitrophenyl)-1H-imidazole-5-carboxylate

: 853069-26-8
tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}-carbamate

Guidance literature:: With iron; acetic acid; at 80 ℃; for 4h;
DOI:10.1016/j.tet.2011.10.015

Reference yield:

: C₂₉H₃₆ClN₅O₄

: 853069-26-8
tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}-carbamate

Guidance literature:: With sodium ethanolate; In ethanol; at 80 ℃; for 1h;

Reference yield:

: 309956-78-3,172603-05-3
(R)-piperidin-3-ylcarbamic acid tert-butyl ester

: 853069-26-8
tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}-carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: isopropyl alcohol / 2.5 h / 20 °C

1.2: 6 h / 0 - 80 °C

2.1: potassium carbonate / acetonitrile / 72 h / 40 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 2.5 h / 0 - 15 °C

4.1: diiodomethane; isopentyl nitrite / toluene / 9 h / 80 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / Reflux

6.1: iron; acetic acid / 4 h / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; diiodomethane; iron; sodium hydride; sodium carbonate; potassium carbonate; acetic acid; isopentyl nitrite; In tetrahydrofuran; 1,2-dimethoxyethane; water; isopropyl alcohol; toluene; acetonitrile; mineral oil; 4.1: Sandmeyer reaction / 5.1: Suzuki-Miyaura coupling;
DOI:10.1016/j.tet.2011.10.015