ethyl 4-amino-2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1-(2-chlorobenzyl)-1H-imidazole-5-carboxylate

Base Information

Chemical Name:ethyl 4-amino-2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1-(2-chlorobenzyl)-1H-imidazole-5-carboxylate
CAS No.:791076-21-6
Molecular Formula:C₂₃H₃₂ClN₅O₄
Molecular Weight:477.991
Hs Code.:

Synonyms:ethyl 4-amino-2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1-(2-chlorobenzyl)-1H-imidazole-5-carboxylate

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Chemical Property of ethyl 4-amino-2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1-(2-chlorobenzyl)-1H-imidazole-5-carboxylate

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Technology Process of ethyl 4-amino-2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1-(2-chlorobenzyl)-1H-imidazole-5-carboxylate

There total 4 articles about ethyl 4-amino-2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1-(2-chlorobenzyl)-1H-imidazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 791076-24-9
ethyl N-[(Z)-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}(cyanoimino)methyl]-N-(2-chlorobenzyl) glycinate

: 791076-21-6
ethyl 4-amino-2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1-(2-chlorobenzyl)-1H-imidazole-5-carboxylate

Guidance literature:: With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 15 ℃; for 2.5h;
DOI:10.1016/j.tet.2011.10.015

Reference yield:

: 1349877-39-9,791076-27-2
ethyl N-[(E)-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}(cyanoimino)methyl]glycinate

: 791076-21-6
ethyl 4-amino-2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1-(2-chlorobenzyl)-1H-imidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 72 h / 40 °C

2: sodium hydride / tetrahydrofuran; mineral oil / 2.5 h / 0 - 15 °C

With sodium hydride; potassium carbonate; In tetrahydrofuran; acetonitrile; mineral oil;
DOI:10.1016/j.tet.2011.10.015

Reference yield:

: 309956-78-3,172603-05-3
(R)-piperidin-3-ylcarbamic acid tert-butyl ester

: 791076-21-6
ethyl 4-amino-2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1-(2-chlorobenzyl)-1H-imidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: isopropyl alcohol / 2.5 h / 20 °C

1.2: 6 h / 0 - 80 °C

2.1: potassium carbonate / acetonitrile / 72 h / 40 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 2.5 h / 0 - 15 °C

With sodium hydride; potassium carbonate; In tetrahydrofuran; isopropyl alcohol; acetonitrile; mineral oil;
DOI:10.1016/j.tet.2011.10.015