(2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)methanamine

Base Information

Chemical Name:(2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)methanamine
CAS No.:1421850-10-3
Molecular Formula:C₁₇H₁₉FN₄S
Molecular Weight:330.429
Hs Code.:

Synonyms:(2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)methanamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)methanamine

Chemical Property:

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Technology Process of (2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)methanamine

There total 8 articles about (2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1421850-09-0
((2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)methyl)carbamic acid

: 1421850-10-3
(2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)methanamine

Guidance literature:: With trifluoroacetic acid; at 20 ℃; for 1h;

Reference yield:

: 1999-00-4
ethyl 3-(4'-fluorophenyl)-3-oxopropionate

: 1421850-10-3
(2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)methanamine

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene / 14 h / 100 °C

1.2: 3 h / 80 °C

2.1: ammonium chloride; benzotriazol-1-ol; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 48 h / 20 °C

3.1: Lawessons reagent / tetrahydrofuran / 1.5 h / 50 °C

4.1: ethanol / 16 h / 80 °C

5.1: sodium hydroxide; water / ethanol / 2.5 h / 20 °C

6.1: triethylamine; diphenylphosphoranyl azide / toluene / 14 h / 20 °C

7.1: trifluoroacetic acid / 1 h / 20 °C

With Lawessons reagent; diphenylphosphoranyl azide; water; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 936084-44-5
ethyl 1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazole-4-carboxylate

: 1421850-10-3
(2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)methanamine

Guidance literature:: Multi-step reaction with 6 steps

1: ammonium chloride; benzotriazol-1-ol; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 48 h / 20 °C

2: Lawessons reagent / tetrahydrofuran / 1.5 h / 50 °C

3: ethanol / 16 h / 80 °C

4: sodium hydroxide; water / ethanol / 2.5 h / 20 °C

5: triethylamine; diphenylphosphoranyl azide / toluene / 14 h / 20 °C

6: trifluoroacetic acid / 1 h / 20 °C

With Lawessons reagent; diphenylphosphoranyl azide; water; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene;