((2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)methyl)carbamic acid

Base Information

Chemical Name:((2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)methyl)carbamic acid
CAS No.:1421850-09-0
Molecular Formula:C₂₂H₂₇FN₄O₂S
Molecular Weight:430.546
Hs Code.:

Synonyms:((2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)methyl)carbamic acid

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Chemical Property of ((2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)methyl)carbamic acid

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Technology Process of ((2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)methyl)carbamic acid

There total 7 articles about ((2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)methyl)carbamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.35%

: 1421848-76-1
2-(2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acetic acid

: 75-65-0
tert-butyl alcohol

: 1421850-09-0
((2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)methyl)carbamic acid

Guidance literature:: With diphenylphosphoranyl azide; triethylamine; In toluene; at 20 ℃; for 14h;

Reference yield:

: 1999-00-4
ethyl 3-(4'-fluorophenyl)-3-oxopropionate

: 1421850-09-0
((2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)methyl)carbamic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene / 14 h / 100 °C

1.2: 3 h / 80 °C

2.1: ammonium chloride; benzotriazol-1-ol; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 48 h / 20 °C

3.1: Lawessons reagent / tetrahydrofuran / 1.5 h / 50 °C

4.1: ethanol / 16 h / 80 °C

5.1: sodium hydroxide; water / ethanol / 2.5 h / 20 °C

6.1: triethylamine; diphenylphosphoranyl azide / toluene / 14 h / 20 °C

With Lawessons reagent; diphenylphosphoranyl azide; water; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 936084-44-5
ethyl 1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazole-4-carboxylate

: 1421850-09-0
((2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)methyl)carbamic acid

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium chloride; benzotriazol-1-ol; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 48 h / 20 °C

2: Lawessons reagent / tetrahydrofuran / 1.5 h / 50 °C

3: ethanol / 16 h / 80 °C

4: sodium hydroxide; water / ethanol / 2.5 h / 20 °C

5: triethylamine; diphenylphosphoranyl azide / toluene / 14 h / 20 °C

With Lawessons reagent; diphenylphosphoranyl azide; water; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene;