O,O-dimethyl α-(2-chloro-4-fluorophenoxyacetoxy)benzylphosphonate

Base Information

• Chemical Name: O,O-dimethyl α-(2-chloro-4-fluorophenoxyacetoxy)benzylphosphonate
• CAS No.: 866145-53-1
• Molecular Formula: C₁₇H₁₇ClFO₆P
• Molecular Weight: 402.744
• Mol file: 866145-53-1.mol

Synonyms:O,O-dimethyl α-(2-chloro-4-fluorophenoxyacetoxy)benzylphosphonate

Chemical Property of O,O-dimethyl α-(2-chloro-4-fluorophenoxyacetoxy)benzylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of O,O-dimethyl α-(2-chloro-4-fluorophenoxyacetoxy)benzylphosphonate

There total 3 articles about O,O-dimethyl α-(2-chloro-4-fluorophenoxyacetoxy)benzylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

dimethyl 1-hydroxy-1-phenylmethylphosphonate (6329-46-0,79296-54-1,97995-93-2,147731-04-2) + 2-(2-chloro-4-fluorophenoxy)acetyl chloride (826990-46-9) → O,O-dimethyl α-(2-chloro-4-fluorophenoxyacetoxy)benzylphosphonate (866145-53-1)

Guidance literature:

With triethylamine; In chloroform; at 2 - 20 ℃;

DOI:10.1021/jf104247w

Reference yield:

benzaldehyde (100-52-7) → O,O-dimethyl α-(2-chloro-4-fluorophenoxyacetoxy)benzylphosphonate (866145-53-1)

Guidance literature:

Multi-step reaction with 2 steps

2: triethylamine / chloroform / 2 - 20 °C

With triethylamine; In chloroform;

DOI:10.1021/jf104247w

Reference yield:

2-(2-chloro-4-fluorophenoxy)acetic acid (399-41-7) → O,O-dimethyl α-(2-chloro-4-fluorophenoxyacetoxy)benzylphosphonate (866145-53-1)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride

2: triethylamine / chloroform / 2 - 20 °C

With thionyl chloride; triethylamine; In chloroform;

DOI:10.1021/jf104247w

upstream raw materials:

dimethyl 1-hydroxy-1-phenylmethylphosphonate

2-(2-chloro-4-fluorophenoxy)acetyl chloride

2-(2-chloro-4-fluorophenoxy)acetic acid

benzaldehyde