(2S,3R,4S,6R)-2-(Benzylamino-methyl)-6-hydroxymethyl-3-methyl-piperidin-4-ol

Base Information

Chemical Name:(2S,3R,4S,6R)-2-(Benzylamino-methyl)-6-hydroxymethyl-3-methyl-piperidin-4-ol
CAS No.:893403-29-7
Molecular Formula:C₁₅H₂₄N₂O₂
Molecular Weight:264.368
Hs Code.:

Synonyms:(2S,3R,4S,6R)-2-(Benzylamino-methyl)-6-hydroxymethyl-3-methyl-piperidin-4-ol

Suppliers and Price of (2S,3R,4S,6R)-2-(Benzylamino-methyl)-6-hydroxymethyl-3-methyl-piperidin-4-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R,4S,6R)-2-(Benzylamino-methyl)-6-hydroxymethyl-3-methyl-piperidin-4-ol

Chemical Property:

Purity/Quality:

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Technology Process of (2S,3R,4S,6R)-2-(Benzylamino-methyl)-6-hydroxymethyl-3-methyl-piperidin-4-ol

There total 8 articles about (2S,3R,4S,6R)-2-(Benzylamino-methyl)-6-hydroxymethyl-3-methyl-piperidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-46-9
benzylamine

: 893403-31-1
(1S,2R,3S,7R)-2-methyl-5,9-dioxa-8-azatricyclo[5.2.1.0^3,8]decan-4-ol

: 893403-29-7
(2S,3R,4S,6R)-2-(Benzylamino-methyl)-6-hydroxymethyl-3-methyl-piperidin-4-ol

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; under 760 Torr;
DOI:10.1016/j.tet.2006.02.044

Reference yield:

: 334994-41-1,863554-80-7
5-(R)-but-2-enyl-morpholin-2-one

: 893403-29-7
(2S,3R,4S,6R)-2-(Benzylamino-methyl)-6-hydroxymethyl-3-methyl-piperidin-4-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / mCPBA; Na₂HPO₄ / CH₂Cl₂ / 0.5 h / -78 °C

2: toluene / 2.5 h / 200 °C

3: toluene / 200 °C

4: LiAlH₄ / tetrahydrofuran / Heating

With disodium hydrogenphosphate; lithium aluminium tetrahydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.tet.2006.02.044

Reference yield:

: 334994-40-0
2-(R,E)-aminohex-4-en-1-ol

: 893403-29-7
(2S,3R,4S,6R)-2-(Benzylamino-methyl)-6-hydroxymethyl-3-methyl-piperidin-4-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 63 percent / (i-Pr)2NEt / acetonitrile / 4 h

2: 84 percent / mCPBA; Na₂HPO₄ / CH₂Cl₂ / 0.5 h / -78 °C

3: toluene / 2.5 h / 200 °C

4: toluene / 200 °C

5: LiAlH₄ / tetrahydrofuran / Heating

With disodium hydrogenphosphate; lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;
DOI:10.1016/j.tet.2006.02.044