(5R,7S,8R,8aS)-2-Benzyl-7-hydroxy-5-hydroxymethyl-8-methyl-hexahydro-imidazo[1,5-a]pyridin-3-one

Base Information

Chemical Name:(5R,7S,8R,8aS)-2-Benzyl-7-hydroxy-5-hydroxymethyl-8-methyl-hexahydro-imidazo[1,5-a]pyridin-3-one
CAS No.:893403-35-5
Molecular Formula:C₁₆H₂₂N₂O₃
Molecular Weight:290.362
Hs Code.:

Synonyms:(5R,7S,8R,8aS)-2-Benzyl-7-hydroxy-5-hydroxymethyl-8-methyl-hexahydro-imidazo[1,5-a]pyridin-3-one

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Chemical Property of (5R,7S,8R,8aS)-2-Benzyl-7-hydroxy-5-hydroxymethyl-8-methyl-hexahydro-imidazo[1,5-a]pyridin-3-one

Chemical Property:

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Technology Process of (5R,7S,8R,8aS)-2-Benzyl-7-hydroxy-5-hydroxymethyl-8-methyl-hexahydro-imidazo[1,5-a]pyridin-3-one

There total 10 articles about (5R,7S,8R,8aS)-2-Benzyl-7-hydroxy-5-hydroxymethyl-8-methyl-hexahydro-imidazo[1,5-a]pyridin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 334994-42-2
(5R)-(but-2-enyl)-4-oxy-5,6-dihydro-[1,4]oxazin-2-one

: 893403-35-5
(5R,7S,8R,8aS)-2-Benzyl-7-hydroxy-5-hydroxymethyl-8-methyl-hexahydro-imidazo[1,5-a]pyridin-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 2.5 h / 200 °C

2: toluene / 200 °C

3: LiAlH₄ / tetrahydrofuran / Heating

4: acetonitrile

With lithium aluminium tetrahydride; In tetrahydrofuran; toluene; acetonitrile;
DOI:10.1016/j.tet.2006.02.044

Reference yield:

: 334994-41-1,863554-80-7
5-(R)-but-2-enyl-morpholin-2-one

: 893403-35-5
(5R,7S,8R,8aS)-2-Benzyl-7-hydroxy-5-hydroxymethyl-8-methyl-hexahydro-imidazo[1,5-a]pyridin-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / mCPBA; Na₂HPO₄ / CH₂Cl₂ / 0.5 h / -78 °C

2: toluene / 2.5 h / 200 °C

3: toluene / 200 °C

4: LiAlH₄ / tetrahydrofuran / Heating

5: acetonitrile

With disodium hydrogenphosphate; lithium aluminium tetrahydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;
DOI:10.1016/j.tet.2006.02.044

Reference yield:

: 81136-82-5
(E)-(R)-2-Amino-hex-4-enoic acid methyl ester

: 893403-35-5
(5R,7S,8R,8aS)-2-Benzyl-7-hydroxy-5-hydroxymethyl-8-methyl-hexahydro-imidazo[1,5-a]pyridin-3-one

Guidance literature:: Multi-step reaction with 7 steps

1: 487 mg / LiAlH₄ / tetrahydrofuran / 3 h / 20 °C

2: 63 percent / (i-Pr)2NEt / acetonitrile / 4 h

3: 84 percent / mCPBA; Na₂HPO₄ / CH₂Cl₂ / 0.5 h / -78 °C

4: toluene / 2.5 h / 200 °C

5: toluene / 200 °C

6: LiAlH₄ / tetrahydrofuran / Heating

7: acetonitrile

With disodium hydrogenphosphate; lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;
DOI:10.1016/j.tet.2006.02.044