ethyl 4,4-difluoro-5-(4-chlorophenyl)-3-oxo-5-(4-methoxyphenyl)amino-pentanoate

Base Information

Chemical Name:ethyl 4,4-difluoro-5-(4-chlorophenyl)-3-oxo-5-(4-methoxyphenyl)amino-pentanoate
CAS No.:497845-53-1
Molecular Formula:C₂₀H₂₀ClF₂NO₄
Molecular Weight:411.833
Hs Code.:

Synonyms:ethyl 4,4-difluoro-5-(4-chlorophenyl)-3-oxo-5-(4-methoxyphenyl)amino-pentanoate

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Chemical Property of ethyl 4,4-difluoro-5-(4-chlorophenyl)-3-oxo-5-(4-methoxyphenyl)amino-pentanoate

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Technology Process of ethyl 4,4-difluoro-5-(4-chlorophenyl)-3-oxo-5-(4-methoxyphenyl)amino-pentanoate

There total 1 articles about ethyl 4,4-difluoro-5-(4-chlorophenyl)-3-oxo-5-(4-methoxyphenyl)amino-pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103749-64-0
(E)-N-(4-chlorobenzylidene)-4-methoxyaniline

: 367922-07-4
ethyl 4-bromo-4,4-difluoro-3-oxybutaneoate

: 497845-53-1
ethyl 4,4-difluoro-5-(4-chlorophenyl)-3-oxo-5-(4-methoxyphenyl)amino-pentanoate

Guidance literature:: With 4 A molecular sieve; copper(l) chloride; zinc; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1021/ol0275670

Reference yield: 82.0%

: 497845-53-1
ethyl 4,4-difluoro-5-(4-chlorophenyl)-3-oxo-5-(4-methoxyphenyl)amino-pentanoate

: 503812-18-8
ethyl 2-diazo-4,4-difluoro-5-(4-chlorophenyl)-3-oxo-5-(4-methoxyphenyl)amino-pentanoate

Guidance literature:: With 4-toluenesulfonyl azide; triethylamine; In benzene; at 0 - 20 ℃;
DOI:10.1021/ol0275670

Reference yield:

: 497845-53-1
ethyl 4,4-difluoro-5-(4-chlorophenyl)-3-oxo-5-(4-methoxyphenyl)amino-pentanoate

: ethyl 5-(4-chlorophenyl)-4-fluoro-3-hydroxy-5-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / TosN₃; Et₃N / benzene / 0 - 20 °C

2: 90 percent / Rh₂(OAc)4 / toluene / 20 h / Heating

With dirhodium tetraacetate; 4-toluenesulfonyl azide; triethylamine; In toluene; benzene;
DOI:10.1021/ol0275670