Ethyl 4-bromo-4,4-difluoro-3-oxobutanoate

Base Information

Chemical Name:Ethyl 4-bromo-4,4-difluoro-3-oxobutanoate
CAS No.:367922-07-4
Molecular Formula:C6H7BrF2O3
Molecular Weight:245.021
Hs Code.:2918300090
European Community (EC) Number:820-336-9
DSSTox Substance ID:DTXSID00462346
Nikkaji Number:J1.795.927A
Wikidata:Q82286867
Mol file:367922-07-4.mol

Synonyms:Ethyl 4-bromo-4,4-difluoro-3-oxobutanoate;367922-07-4;Ethyl 4-bromo-4,4-difluoro-3-oxobutanoate, Ethyl 4-bromo-4,4-difluoro-3-oxobutyrate;ethyl 4-bromo-4,4-difluoroacetoacetate;SCHEMBL17275140;DTXSID00462346;DCOGKVHCIAKKQH-UHFFFAOYSA-N;Ethyl4-bromo-4,4-difluoro-3-oxobutanoate;CS-0245898;EN300-313110

Suppliers and Price of Ethyl 4-bromo-4,4-difluoro-3-oxobutanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
Ethyl4-bromo-4,4-difluoro-3-oxobutanoate
10g
$ 4977.00

AK Scientific
Ethyl4-bromo-4,4-difluoro-3-oxobutanoate
500mg
$ 1008.00

Total 1 raw suppliers

Chemical Property of Ethyl 4-bromo-4,4-difluoro-3-oxobutanoate

Chemical Property:

PSA：43.37000
LogP:1.49640
XLogP3:1.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:243.95466
Heavy Atom Count:12
Complexity:193

Purity/Quality:

98%+ ^*data from raw suppliers

Ethyl4-bromo-4,4-difluoro-3-oxobutanoate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)CC(=O)C(F)(F)Br

Technology Process of Ethyl 4-bromo-4,4-difluoro-3-oxobutanoate

There total 7 articles about Ethyl 4-bromo-4,4-difluoro-3-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 667-27-6
Ethyl bromodifluoroacetate

: 141-78-6
ethyl acetate

: 367922-07-4
ethyl 4-bromo-4,4-difluoro-3-oxybutaneoate

Guidance literature:: ethyl acetate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -75 ℃; for 1h;

Ethyl bromodifluoroacetate; In tetrahydrofuran; at -75 ℃; for 1h;

Reference yield:

: 683-98-7
methyl bromodifluoroacetate

: 141-78-6
ethyl acetate

: 367922-07-4
ethyl 4-bromo-4,4-difluoro-3-oxybutaneoate

Guidance literature:: ethyl acetate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h;

methyl bromodifluoroacetate; In tetrahydrofuran; at -78 ℃; for 3h;
DOI:10.1016/j.tet.2006.12.045

Reference yield:

: 667-27-6
Ethyl bromodifluoroacetate

: 141-78-6
ethyl acetate

: 4-bromo-4,4-difluoro-3,3-dihydroxy-butyric acid ethyl ester

: 367922-07-4
ethyl 4-bromo-4,4-difluoro-3-oxybutaneoate

Guidance literature:: ethyl acetate; With n-butyllithium; diisopropylamine; In diethyl ether; at -75 ℃; for 0.333333h;

Ethyl bromodifluoroacetate; In diethyl ether; at -75 ℃; for 3h;
DOI:10.1007/s11172-011-0114-y