tert-butyl (3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)propyl)carbamate

Base Information

Chemical Name:tert-butyl (3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)propyl)carbamate
CAS No.:1596369-23-1
Molecular Formula:C₂₁H₂₃F₃IN₃O₄
Molecular Weight:565.331
Hs Code.:

Synonyms:tert-butyl (3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)propyl)carbamate

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Chemical Property of tert-butyl (3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)propyl)carbamate

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Technology Process of tert-butyl (3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)propyl)carbamate

There total 3 articles about tert-butyl (3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)propyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 391211-97-5
3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzoic acid

: 847609-99-8
3-(aminooxy)propylcarbamic acid tert-butyl ester

: 1596369-23-1
tert-butyl (3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)propyl)carbamate

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.3390/molecules181113957

Reference yield:

: 58885-58-8
N-tert-butoxycarbonyl-3-aminopropanol

: 1596369-23-1
tert-butyl (3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)propyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; diethylazodicarboxylate / dichloromethane / 24 h / 20 °C

2: hydrazine / ethanol / 2 h / 20 °C

3: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane; tetrahydrofuran / 20 °C / Inert atmosphere

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; hydrazine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.3390/molecules181113957

Reference yield:

: 894414-29-0
C₁₆H₂₀N₂O₅

: 1596369-23-1
tert-butyl (3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)propyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine / ethanol / 2 h / 20 °C

2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane; tetrahydrofuran / 20 °C / Inert atmosphere

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; hydrazine; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.3390/molecules181113957