2-(4-(((3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)(1-methylpiperidin-4-yl)amino)methyl)phenyl)acetic acid

Base Information

Chemical Name:2-(4-(((3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)(1-methylpiperidin-4-yl)amino)methyl)phenyl)acetic acid
CAS No.:1080007-62-0
Molecular Formula:C₃₂H₄₂N₆O₂
Molecular Weight:542.724
Hs Code.:

Synonyms:2-(4-(((3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)(1-methylpiperidin-4-yl)amino)methyl)phenyl)acetic acid

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Chemical Property of 2-(4-(((3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)(1-methylpiperidin-4-yl)amino)methyl)phenyl)acetic acid

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Technology Process of 2-(4-(((3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)(1-methylpiperidin-4-yl)amino)methyl)phenyl)acetic acid

There total 9 articles about 2-(4-(((3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)(1-methylpiperidin-4-yl)amino)methyl)phenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1080007-58-4
2-butyl-1-(3-(1-methylpiperidin-4-ylamino)propyl)-1H-imidazo[4,5-c]quinolin-4-amine

: 34841-47-9
2-(4-formylphenyl)acetic acid

: 1080007-62-0
2-(4-(((3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)(1-methylpiperidin-4-yl)amino)methyl)phenyl)acetic acid

Guidance literature:: 2-butyl-1-(3-(1-methylpiperidin-4-ylamino)propyl)-1H-imidazo[4,5-c]quinolin-4-amine; 2-(4-formylphenyl)acetic acid; With sodium tris(acetoxy)borohydride; In 1-methyl-pyrrolidin-2-one; at 20 - 50 ℃; for 24h;

With methanol; acetic acid; In 1-methyl-pyrrolidin-2-one;

Reference yield:

: 611-36-9
quinolin-4-ol

: 1080007-62-0
2-(4-(((3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)(1-methylpiperidin-4-yl)amino)methyl)phenyl)acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: nitric acid; propionic acid / 1.75 h / 125 °C / Heating / reflux

2.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 2.5 h / Heating / reflux

2.2: 0 °C

3.1: hydrogen / 1% platinum on charcoal / tetrahydrofuran / 72 h / 20 °C / 2250.23 Torr

4.1: 1-methyl-pyrrolidin-2-one / 73.5 h / 20 - 80 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 5 - 20 °C

6.1: ammonia; p-toluenesulfonyl chloride / dichloromethane; water / 2 h / 0 - 20 °C

7.1: trifluoroacetic acid / dichloromethane / 0.33 h

8.1: sodium tris(acetoxy)borohydride / 1-methyl-pyrrolidin-2-one / 3 h / 20 - 50 °C

9.1: sodium tris(acetoxy)borohydride / 1-methyl-pyrrolidin-2-one / 24 h / 20 - 50 °C

With thionyl chloride; ammonia; hydrogen; nitric acid; sodium tris(acetoxy)borohydride; propionic acid; p-toluenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; 1% platinum on charcoal; N,N-dimethyl-formamide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water;

Reference yield:

: 860173-10-0
tert-butyl {3-[(3-nitroquinolin-4-yl)amino]propyl}carbamate

: 1080007-62-0
2-(4-(((3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)(1-methylpiperidin-4-yl)amino)methyl)phenyl)acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogen / 1% platinum on charcoal / tetrahydrofuran / 72 h / 20 °C / 2250.23 Torr

2: 1-methyl-pyrrolidin-2-one / 73.5 h / 20 - 80 °C

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 5 - 20 °C

4: ammonia; p-toluenesulfonyl chloride / dichloromethane; water / 2 h / 0 - 20 °C

5: trifluoroacetic acid / dichloromethane / 0.33 h

6: sodium tris(acetoxy)borohydride / 1-methyl-pyrrolidin-2-one / 3 h / 20 - 50 °C

7: sodium tris(acetoxy)borohydride / 1-methyl-pyrrolidin-2-one / 24 h / 20 - 50 °C

With ammonia; hydrogen; sodium tris(acetoxy)borohydride; p-toluenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; 1% platinum on charcoal; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water;