34841-47-9

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-Formylphenyl)acetic acid is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to be readily incorporated into complex organic molecules. Its presence in the molecular structure can contribute to the development of new drugs with specific therapeutic properties.
Used in Organic Compounds Synthesis:
In the field of organic chemistry, 2-(4-Formylphenyl)acetic acid is utilized as a versatile building block for the production of a wide range of materials. Its reactivity and structural features allow for the creation of diverse organic compounds with potential applications in various industries.
Used in Chemical Industry:
2-(4-Formylphenyl)acetic acid is employed in the chemical industry as a precursor for the development of specialty chemicals. Its unique structure and reactivity make it suitable for the synthesis of advanced materials with specific chemical and physical properties, contributing to the advancement of various chemical processes and products.

Upstream product

• 73401-74-8 4-hydroxymethylphenylacetic acid 
• 5462-71-5 4-cyanophenylacetic acid 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 
• 13737-36-5 4-bromophenylacetic acid 
• 622-47-9 4-tolylacetic acid 
• 333389-49-4 4-(2-(ethoxycarbonyl)vinyl)phenylacetic acid 
• 7529-22-8 4-methylmorpholine N-oxide 
• 96524-70-8 methyl 2-(4-formylphenyl)acetate 
• 43153-12-4 ethyl 2-(4-formylphenyl)acetate 

Downstream Products

• 2406-73-7 (4-benzothiazol-2-yl-phenyl)-acetic acid 
• 63476-32-4 [4-(1-Hydroxy-decyl)-phenyl]-acetic acid 
• 154349-03-8 (E)-2-[4-(3-methoxy-3-oxoprop-1-en-1-yl)phenyl]acetic acid 
• 923565-67-7 4-(2-(4-((4-fluorophenyl)amino)-1-piperidinyl)-2-oxoethyl)-benzaldehyde 
• 104-87-0 4-methyl-benzaldehyde 
• 1057854-36-0 C₂₂H₁₉N₃O₃ 
• 1256337-17-3 3-[2-(2-(4-formyl-phenyl)-acetylamino)-2-(2,9,9-trimethyl-3,5-doxa-4-bora-tricyclo[6.1.1.0.(2,6)]dec-4-yl)-ethyl]-2-methoxy-benzoic acid tert-butyl ester 
• 1373764-61-4 N-(4-formylphenylacetyl)-1,3,4,9-tetrahydro-β-carboline 
• 1611455-12-9 C₂₇H₂₃Cl₂F₂NO₆ 
• 154349-04-9 (E)-4-(2-methoxycarbonylvinyl)phenylacetyl chloride 
• 105-07-7 4-cyanobenzaldehyde 
• 623-27-8 terephthalaldehyde, 

Relevant academic research and scientific papers

Analogues of 2′-hydroxychalcone with modified C4-substituents as the inhibitors against human acetylcholinesterase

A series of C4-substituted tertiary nitrogen-bearing 2′-hydroxychalcones were designed and synthesised based on a previous mixed type acetylcholinesterase inhibitor. Majority of the 2′-hydroxychalcone analogues displayed a better inhibition against acetyl

Introducing aldehyde functionality to proteins using ligand-directed affinity labeling

Aldehyde is a versatile chemical handle for protein modification. Although many methods have been developed to label proteins with aldehyde, target-specific methods amenable to endogenous proteins are limited. Here, we report a simple affinity probe strategy to introduce aldehydes to native proteins. Notably, the probe contains a latent aldehyde functionality that is only exposed upon target binding, thereby enabling a one-pot labeling procedure.

An Efficient One–pot Procedure for the Direct Preparation of 4,5-Dihydroisoxazoles from Amides

A Mo(CO)6 (molybdenumhexacarbonyl) catalyzed reductive functionalization of amides to afford 5-amino substituted 4,5-dihydroisoxazoles is presented. The reduction of amides generates reactive enamines, which upon the addition of hydroximinoyl chlorides and base undergoes a 1,3-dipolar cycloaddition reaction that gives access to the desired heterocyclic compounds. The transformation of amides is highly chemoselective and tolerates functional groups such as nitro, nitriles, esters, and ketones. Furthermore, a versatile scope of 4,5-dihydroisoxazoles derived from a variety of hydroximinoyl chlorides and amides is demonstrated. (Figure presented.).

Facile preparation of pyrimidinediones and thioacrylamides: Via reductive functionalization of amides

The development of an efficient protocol for the reductive functionalization of amides into pyrimidinediones and amino-substituted thioacrylamides is presented. Enamines are generated in a highly chemoselective amide hydrosilylation reaction catalyzed by

Method for synthesizing aromatic aldehyde, aromatic ketone and aromatic ester through catalytically oxidizing alkyl aromatic compound by iron

The invention discloses a method for synthesizing aromatic aldehyde, aromatic ketone and aromatic ester through catalytically oxidizing an alkyl aromatic compound by iron, and belongs to the technical field of catalytic synthesis. According to the method, a low-cost and environment-friendly iron catalyst is used under a normal pressure; under the action of hydrogen and silicon reagents serving as an accelerant and an oxidant, a side chain of an aromatic hydrocarbon is oxidized into a carbonyl group for generating the corresponding aromatic aldehyde, aromatic ketone and aromatic ester. The method for preparing the aromatic aldehyde, the aromatic ketone and the aromatic ester through a catalytic oxidation reaction, which is provided by the invention, has numerous advantages that a catalyst, reaction raw materials, the oxidant and a silicon reagent are wide in sources and good in stability and is low-cost and environment-friendly; the alkyl aromatic compound is metered to participate in a reaction; the reaction condition is mild; the compatibility of functional groups is good; the scope of application is wide; the reaction selectivity is good; in an optimized reaction condition, the separation yield of a target product can be up to approximately 95 percent.

3,5-DICHLORO,4-(3,4-(CYCLO-)ALKOXYPHENYL)- 2-CARBONYLOXY)ETHYL)PYRIDINE DERIVATIVES AS PDE-4 INHIBITORS

The invention relates to novel 3,5-dichloro,4-(3,4-(cyclo-) alkoxyphenyl)-2-carbonyloxy)ethyl)pyridine compounds which are both inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.

PHENYLETHYLPYRIDINE DERIVATIVES AS PDE4-INHIBITORS

The invention relates to novel compounds which are both inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.

NOVEL COMPOUNDS

Compounds of formula (I) defined herein are both inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of a disease of the respiratory tract characterized by airway obstruction.

SPIRO-SUBSTITUTED OXINDOLE DERIVATIVES HAVING AMPK ACTIVITY

The present invention relates to compounds of formula (I), which have valuable pharmacological properties, in particular are activators of AMPK and which are therefore useful in the treatment of certain disorders that can be prevented or treated by activation of this receptor. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.

OLEFIN SUBSTITUTED OXINDOLES HAVING AMPK ACTIVITY

The present invention relates to compounds of formula (I), which have valuable pharmacological properties, in particular are activators of AMPK and which are therefore useful in the treatment of certain disorders that can be prevented or treated by activation of this receptor. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.