N-(3,4-difluoro-benzyl)-N-(6-methoxy-benzo[b]thiophen-2-yl)-pyridin-3-yl-sulfonamide

Base Information

Chemical Name:N-(3,4-difluoro-benzyl)-N-(6-methoxy-benzo[b]thiophen-2-yl)-pyridin-3-yl-sulfonamide
CAS No.:1104630-91-2
Molecular Formula:C₂₁H₁₆F₂N₂O₃S₂
Molecular Weight:446.498
Hs Code.:

Synonyms:N-(3,4-difluoro-benzyl)-N-(6-methoxy-benzo[b]thiophen-2-yl)-pyridin-3-yl-sulfonamide

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Chemical Property of N-(3,4-difluoro-benzyl)-N-(6-methoxy-benzo[b]thiophen-2-yl)-pyridin-3-yl-sulfonamide

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Technology Process of N-(3,4-difluoro-benzyl)-N-(6-methoxy-benzo[b]thiophen-2-yl)-pyridin-3-yl-sulfonamide

There total 5 articles about N-(3,4-difluoro-benzyl)-N-(6-methoxy-benzo[b]thiophen-2-yl)-pyridin-3-yl-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1104630-90-1
N-(6-methoxy-benzo[b]thiophen-2-yl)-pyridin-3-yl-sulfonamide

: 85118-01-0
alpha-bromo-3,4-difluorotoluene

: 1104630-91-2
N-(3,4-difluoro-benzyl)-N-(6-methoxy-benzo[b]thiophen-2-yl)-pyridin-3-yl-sulfonamide

Guidance literature:: N-(6-methoxy-benzo[b]thiophen-2-yl)-pyridin-3-yl-sulfonamide; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 0.5h;

alpha-bromo-3,4-difluorotoluene; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield:

: 550998-58-8
6-methoxybenzo[b]thiophene-2-carboxylic acid methyl ester

: 1104630-91-2
N-(3,4-difluoro-benzyl)-N-(6-methoxy-benzo[b]thiophen-2-yl)-pyridin-3-yl-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; methanol / 18 h / 65 °C

2.1: N-ethyl-N,N-diisopropylamine; diphenyl phosphoryl azide / 18 h / Reflux

3.1: hydrogenchloride / ethyl acetate / 18 h / 20 °C

4.1: pyridine / 2 h / 0 - 20 °C

5.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

5.2: 18 h / 20 °C

With hydrogenchloride; methanol; diphenyl phosphoryl azide; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; pyridine; ethyl acetate;

Reference yield:

: 102539-79-7
6-methoxybenzo[b]thiophene-2-carboxylic acid

: 1104630-91-2
N-(3,4-difluoro-benzyl)-N-(6-methoxy-benzo[b]thiophen-2-yl)-pyridin-3-yl-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; diphenyl phosphoryl azide / 18 h / Reflux

2.1: hydrogenchloride / ethyl acetate / 18 h / 20 °C

3.1: pyridine / 2 h / 0 - 20 °C

4.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

4.2: 18 h / 20 °C

With hydrogenchloride; diphenyl phosphoryl azide; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; pyridine; ethyl acetate;