7-(5-chloro-2-hydroxy-3,4,6-trimethylphenyl)-7-(4-fluorophenyl)heptanoic acid

Base Information

Chemical Name:7-(5-chloro-2-hydroxy-3,4,6-trimethylphenyl)-7-(4-fluorophenyl)heptanoic acid
CAS No.:121099-86-3
Molecular Formula:C₂₂H₂₆ClFO₃
Molecular Weight:392.898
Hs Code.:

Synonyms:7-(5-chloro-2-hydroxy-3,4,6-trimethylphenyl)-7-(4-fluorophenyl)heptanoic acid

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Chemical Property of 7-(5-chloro-2-hydroxy-3,4,6-trimethylphenyl)-7-(4-fluorophenyl)heptanoic acid

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Technology Process of 7-(5-chloro-2-hydroxy-3,4,6-trimethylphenyl)-7-(4-fluorophenyl)heptanoic acid

There total 4 articles about 7-(5-chloro-2-hydroxy-3,4,6-trimethylphenyl)-7-(4-fluorophenyl)heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 121099-87-4
ethyl 7-(5-chloro-2-hydroxy-3,4,6-trimethylphenyl)-7-(4-fluorophenyl)heptanoate

: 121099-86-3
7-(5-chloro-2-hydroxy-3,4,6-trimethylphenyl)-7-(4-fluorophenyl)heptanoic acid

Guidance literature:: With sodium hydroxide; In methanol; for 15h; Ambient temperature;
DOI:10.1021/jm00090a009

Reference yield:

: 697-82-5
2,3,5-trimethylphenol

: 121099-86-3
7-(5-chloro-2-hydroxy-3,4,6-trimethylphenyl)-7-(4-fluorophenyl)heptanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: BF₃*Et₂O / 1,2-dichloro-ethane / 6 h / 60 °C

2: 92 percent / SO₂Cl₂ / 1 h / Ambient temperature

3: 79 percent / 1 N NaOH / methanol / 15 h / Ambient temperature

With sodium hydroxide; sulfuryl dichloride; boron trifluoride diethyl etherate; In methanol; 1,2-dichloro-ethane;
DOI:10.1021/jm00090a009

Reference yield:

: 140875-13-4
7-(4-Fluoro-phenyl)-7-hydroxy-heptanoic acid ethyl ester

: 121099-86-3
7-(5-chloro-2-hydroxy-3,4,6-trimethylphenyl)-7-(4-fluorophenyl)heptanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: BF₃*Et₂O / 1,2-dichloro-ethane / 6 h / 60 °C

2: 92 percent / SO₂Cl₂ / 1 h / Ambient temperature

3: 79 percent / 1 N NaOH / methanol / 15 h / Ambient temperature

With sodium hydroxide; sulfuryl dichloride; boron trifluoride diethyl etherate; In methanol; 1,2-dichloro-ethane;
DOI:10.1021/jm00090a009