(S)-2-((R)-hydroxylmethyl)-5-(3,4,5-trifluorophenyl)pyrrolidine-1-carboxylic acid t-butyl ester

Base Information

Chemical Name:(S)-2-((R)-hydroxylmethyl)-5-(3,4,5-trifluorophenyl)pyrrolidine-1-carboxylic acid t-butyl ester
CAS No.:1004791-33-6
Molecular Formula:C₁₆H₂₀F₃NO₃
Molecular Weight:331.335
Hs Code.:

Synonyms:(S)-2-((R)-hydroxylmethyl)-5-(3,4,5-trifluorophenyl)pyrrolidine-1-carboxylic acid t-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-((R)-hydroxylmethyl)-5-(3,4,5-trifluorophenyl)pyrrolidine-1-carboxylic acid t-butyl ester

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Technology Process of (S)-2-((R)-hydroxylmethyl)-5-(3,4,5-trifluorophenyl)pyrrolidine-1-carboxylic acid t-butyl ester

There total 1 articles about (S)-2-((R)-hydroxylmethyl)-5-(3,4,5-trifluorophenyl)pyrrolidine-1-carboxylic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1004791-32-5
(2R,5S)-5-(3,4,5-trifluorophenyl)-pyrrolidine-1,2-dicarboxylic acid 1-t-butyl ester 2-ethyl ester

: 1004791-33-6
(S)-2-((R)-hydroxylmethyl)-5-(3,4,5-trifluorophenyl)pyrrolidine-1-carboxylic acid t-butyl ester

Guidance literature:: With lithium borohydride; In tetrahydrofuran; at 0 - 20 ℃; for 13.5h;

Reference yield:

: 1004791-33-6
(S)-2-((R)-hydroxylmethyl)-5-(3,4,5-trifluorophenyl)pyrrolidine-1-carboxylic acid t-butyl ester

: 75-16-1
methylmagnesium bromide

: (S)-2-((R)-1-hydroxylethyl)-5-(3,4,5-trifluorophenyl)pyrrolidine-1-carboxylic acid t-butyl ester

Guidance literature:: (S)-2-((R)-hydroxylmethyl)-5-(3,4,5-trifluorophenyl)pyrrolidine-1-carboxylic acid t-butyl ester; With oxalyl dichloride; dimethyl sulfoxide; In tetrahydrofuran; at -78 ℃; for 0.666667h;

With triethylamine; In tetrahydrofuran; at -78 ℃; for 1h;

methylmagnesium bromide; With ammonium chloride; more than 3 stages;