tert-butyl N-[3-(4-(2-[2-(bromomethyl)-6-[ethoxy(phenyl)phosphoryl]pyridin-4-yl]ethynyl)phenoxy)propyl]carbamate

Base Information

Chemical Name:tert-butyl N-[3-(4-(2-[2-(bromomethyl)-6-[ethoxy(phenyl)phosphoryl]pyridin-4-yl]ethynyl)phenoxy)propyl]carbamate
CAS No.:1417729-17-9
Molecular Formula:C₃₀H₃₄BrN₂O₅P
Molecular Weight:613.488
Hs Code.:

Synonyms:tert-butyl N-[3-(4-(2-[2-(bromomethyl)-6-[ethoxy(phenyl)phosphoryl]pyridin-4-yl]ethynyl)phenoxy)propyl]carbamate

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Chemical Property of tert-butyl N-[3-(4-(2-[2-(bromomethyl)-6-[ethoxy(phenyl)phosphoryl]pyridin-4-yl]ethynyl)phenoxy)propyl]carbamate

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Technology Process of tert-butyl N-[3-(4-(2-[2-(bromomethyl)-6-[ethoxy(phenyl)phosphoryl]pyridin-4-yl]ethynyl)phenoxy)propyl]carbamate

There total 15 articles about tert-butyl N-[3-(4-(2-[2-(bromomethyl)-6-[ethoxy(phenyl)phosphoryl]pyridin-4-yl]ethynyl)phenoxy)propyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: C₃₀H₃₅N₂O₆P

: 1417729-17-9
tert-butyl N-[3-(4-(2-[2-(bromomethyl)-6-[ethoxy(phenyl)phosphoryl]pyridin-4-yl]ethynyl)phenoxy)propyl]carbamate

Guidance literature:: With phosphorus tribromide; In dichloromethane; at 0 - 20 ℃; for 1.25h;

Reference yield:

: 83948-53-2
3-bromopropylamine tert-butylcarbamate

: 1417729-17-9
tert-butyl N-[3-(4-(2-[2-(bromomethyl)-6-[ethoxy(phenyl)phosphoryl]pyridin-4-yl]ethynyl)phenoxy)propyl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / acetonitrile / 1 h / Reflux

1.2: 12 h / Reflux

2.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 12 h / 20 °C

3.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; triethylamine / tetrahydrofuran / 3 h / 65 °C / Inert atmosphere

4.1: sodium; ethanol / 0.67 h / Inert atmosphere; Heating

5.1: phosphorus tribromide / dichloromethane / 1.25 h / 0 - 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ethanol; tetrabutyl ammonium fluoride; sodium; phosphorus tribromide; sodium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;

Reference yield:

: 913172-10-8
tert-butyl 3-(4-iodophenoxy)propylcarbamate

: 1417729-17-9
tert-butyl N-[3-(4-(2-[2-(bromomethyl)-6-[ethoxy(phenyl)phosphoryl]pyridin-4-yl]ethynyl)phenoxy)propyl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 12 h / 20 °C

2: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; triethylamine / tetrahydrofuran / 3 h / 65 °C / Inert atmosphere

3: sodium; ethanol / 0.67 h / Inert atmosphere; Heating

4: phosphorus tribromide / dichloromethane / 1.25 h / 0 - 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ethanol; tetrabutyl ammonium fluoride; sodium; phosphorus tribromide; triethylamine; In tetrahydrofuran; dichloromethane;