1-acetyl-6-amino-8-methoxy-4-phenyl-1,2,3,4-tetrahydro-2,2,4,7-tetramethylquinoline

Base Information

• Chemical Name: 1-acetyl-6-amino-8-methoxy-4-phenyl-1,2,3,4-tetrahydro-2,2,4,7-tetramethylquinoline
• CAS No.: 487065-17-8
• Molecular Formula: C₂₁H₂₆N₂O₂
• Molecular Weight: 338.45
• Mol file: 487065-17-8.mol

Synonyms:1-acetyl-6-amino-8-methoxy-4-phenyl-1,2,3,4-tetrahydro-2,2,4,7-tetramethylquinoline

Chemical Property of 1-acetyl-6-amino-8-methoxy-4-phenyl-1,2,3,4-tetrahydro-2,2,4,7-tetramethylquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-acetyl-6-amino-8-methoxy-4-phenyl-1,2,3,4-tetrahydro-2,2,4,7-tetramethylquinoline

There total 3 articles about 1-acetyl-6-amino-8-methoxy-4-phenyl-1,2,3,4-tetrahydro-2,2,4,7-tetramethylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(tert-butoxycarbonyl)-3-methoxy-1,4-phenylenediamine (487065-22-5) → 1-acetyl-6-amino-8-methoxy-4-phenyl-1,2,3,4-tetrahydro-2,2,4,7-tetramethylquinoline (487065-17-8)

Guidance literature:

Multi-step reaction with 3 steps

1: iodine; 4-tert-butylcatechol; magnesium sulfate / 20 h / Heating

2: pyridine / toluene / 1 h

3: AlCl₃ / 3 h / 70 °C

With pyridine; aluminium trichloride; 4-tert-Butylcatechol; iodine; magnesium sulfate; In toluene;

DOI:10.1021/jm049676l

Reference yield:

(8-methoxy-2,2,4-trimethyl-1,2-dihydro-quinolin-6-yl)-carbamic acid tert-butyl ester → 1-acetyl-6-amino-8-methoxy-4-phenyl-1,2,3,4-tetrahydro-2,2,4,7-tetramethylquinoline (487065-17-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / toluene / 1 h

2: AlCl₃ / 3 h / 70 °C

With pyridine; aluminium trichloride; In toluene;

DOI:10.1021/jm049676l

Reference yield:

1-(6-amino-8-methoxy-2,2,4-trimethyl-2H-quinolin-1-yl)-ethanone + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 1-acetyl-6-amino-8-methoxy-4-phenyl-1,2,3,4-tetrahydro-2,2,4,7-tetramethylquinoline (487065-17-8)

Guidance literature:

With aluminium trichloride; at 70 ℃; for 3h;

DOI:10.1021/jm049676l

upstream raw materials:

benzene

N-(tert-butoxycarbonyl)-3-methoxy-1,4-phenylenediamine