Dimethyl-d6-amine

Base Information

• Chemical Name: Dimethyl-d6-amine
• CAS No.: 14802-36-9
• Molecular Formula: C2H D6 N
• Molecular Weight: 51.0366
• European Community (EC) Number: 686-068-8
• DSSTox Substance ID: DTXSID70473742
• Nikkaji Number: J291.231G
• Wikidata: Q82303347
• Mol file: 14802-36-9.mol

Synonyms:Dimethyl-d6-amine;14802-36-9;DIMETHYL-D 6-AMINE;Methan-d3-amine, N-(methyl-d3)- (9CI);1,1,1-trideuterio-N-(trideuteriomethyl)methanamine;N,N-di(trideuteromethyl)amine;DTXSID70473742;Dimethyl-d6-amine, 99 atom % D;AKOS015895003;D99306

Chemical Property of Dimethyl-d6-amine

Chemical Property:

• Vapor Pressure: 1277 mm Hg ( 20 °C)
• Melting Point: −93 °C(lit.)
• Refractive Index: 1.344
• Boiling Point: 7 °C(lit.)
• PSA: 12.03000
• Density: 0.726g/cm³
• LogP: 0.22650
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 51.095509703
• Heavy Atom Count: 3
• Complexity: 2.8

Purity/Quality:

99% ^*data from raw suppliers

Dimethyl-d6-amine 99 atom % D ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F,C,F+
• Statements: 11-20/21/22-34-20/22-12
• Safety Statements: 16-26-27-36/37/39-45-29-3

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC
• Isomeric SMILES: [2H]C([2H])([2H])NC([2H])([2H])[2H]

Technology Process of Dimethyl-d6-amine

There total 4 articles about Dimethyl-d6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

C9H7(2)H6N → dimethylamine-D6 (14802-36-9)

Guidance literature:

With hydrogenchloride; 10% palladium hydroxide on charcoal; palladium 10% on activated carbon; hydrogen; In methanol; water; at 50 ℃; for 24h; under 760.051 Torr;

Reference yield: 65.0%

N,N-Bis-(D3-methyl)-p-toluolsulfonamid (97941-90-7) → dimethylamine-D6 (14802-36-9)

Guidance literature:

With sulfuric acid; for 6h; Heating;

DOI:10.1021/jp964077e

Reference yield:

d7-N,N-dimethylformamide (4472-41-7,185990-36-7) + benzylamine (100-46-9) → dimethylamine-D6 (14802-36-9) + N-benzyl(2H)formamide (85995-47-7)

Guidance literature:

With cerium(IV) oxide; at 180 ℃; for 8h; Temperature; Sealed tube;

DOI:10.1039/c3cc48400a

upstream raw materials:

N,N-Bis-(D₃-methyl)-p-toluolsulfonamid

d₇-N,N-dimethylformamide

benzylamine

Downstream raw materials:

(R,S)-3-[(1-di(2H3)methylamino)ethyl]phenol

2-{2-(dimethyl-d6-aminomethyl)phenyl}-4,4-diphenyl-1,3,2-dioxaborolane

N,N-dimethylacetamide-d6

N,N-dimethyl-d₆-formamide

Refernces

• 1、 Yang, Luo,Lin, Jie,Kang, Lei,Zhou, Wang,Ma, Da-You. "Lewis Acid-Catalyzed Reductive Amination of Aldehydes and Ketones with N,N-Dimethylformamide as Dimethylamino Source, Reductant and Solvent". supporting information. p. 485 - 490. Retrieved 2018/01/15.
• 2、 Nguyen, Viet Q.,Sadilek, Martin,Ferrier, Jordan,Frank, Aaron J.,Turec?ek, Frantis?ek. "Metastable states of dimethylammonium, (CH3)2NH2.". . p. 3789 - 3799. Retrieved 2007/10/03.