(S)-tert-butyl 1-(p-nitrophenoxycarbonylamino)-3-cyclohexylpropan-2-ylcarbamate

Base Information

Chemical Name:(S)-tert-butyl 1-(p-nitrophenoxycarbonylamino)-3-cyclohexylpropan-2-ylcarbamate
CAS No.:884513-80-8
Molecular Formula:C₂₁H₃₁N₃O₆
Molecular Weight:421.494
Hs Code.:

Synonyms:(S)-tert-butyl 1-(p-nitrophenoxycarbonylamino)-3-cyclohexylpropan-2-ylcarbamate

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Chemical Property of (S)-tert-butyl 1-(p-nitrophenoxycarbonylamino)-3-cyclohexylpropan-2-ylcarbamate

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Technology Process of (S)-tert-butyl 1-(p-nitrophenoxycarbonylamino)-3-cyclohexylpropan-2-ylcarbamate

There total 4 articles about (S)-tert-butyl 1-(p-nitrophenoxycarbonylamino)-3-cyclohexylpropan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7693-46-1
4-Nitrophenyl chloroformate

: 149423-46-1
(S)-tert-butyl (1-amino-3-cyclohexylpropan-2-yl)carbamate

: 884513-80-8
(S)-tert-butyl 1-(p-nitrophenoxycarbonylamino)-3-cyclohexylpropan-2-ylcarbamate

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; acetonitrile; at 20 ℃; for 2h;
DOI:10.1021/ml200137x

Reference yield:

: 884511-11-9
(S)-tert-butyl (1-azido-3-cyclohexylpropan-2-yl)carbamate

: 884513-80-8
(S)-tert-butyl 1-(p-nitrophenoxycarbonylamino)-3-cyclohexylpropan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr

2: sodium hydrogencarbonate / tetrahydrofuran; acetonitrile / 2 h / 20 °C

With palladium on activated charcoal; hydrogen; sodium hydrogencarbonate; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/ml200137x

Reference yield:

: 103322-56-1
tert-butyl [(1S)-2-cyclohexyl-1-(hydroxymethyl)ethyl]carbamate

: 884513-80-8
(S)-tert-butyl 1-(p-nitrophenoxycarbonylamino)-3-cyclohexylpropan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 1.5 h / -20 - 0 °C

2: sodium azide / N,N-dimethyl-formamide / 16 h / 80 °C

3: palladium on activated charcoal; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr

4: sodium hydrogencarbonate / tetrahydrofuran; acetonitrile / 2 h / 20 °C

With sodium azide; palladium on activated charcoal; hydrogen; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ml200137x