1-(6-(4-methoxyphenyl)-2-(methylthio)thieno[3,2-b]thiophen-3-yl)-2,2-dimethylpropan-1-one

Base Information

Chemical Name:1-(6-(4-methoxyphenyl)-2-(methylthio)thieno[3,2-b]thiophen-3-yl)-2,2-dimethylpropan-1-one
CAS No.:1268375-57-0
Molecular Formula:C₁₉H₂₀O₂S₃
Molecular Weight:376.565
Hs Code.:

Synonyms:1-(6-(4-methoxyphenyl)-2-(methylthio)thieno[3,2-b]thiophen-3-yl)-2,2-dimethylpropan-1-one

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Chemical Property of 1-(6-(4-methoxyphenyl)-2-(methylthio)thieno[3,2-b]thiophen-3-yl)-2,2-dimethylpropan-1-one

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Technology Process of 1-(6-(4-methoxyphenyl)-2-(methylthio)thieno[3,2-b]thiophen-3-yl)-2,2-dimethylpropan-1-one

There total 7 articles about 1-(6-(4-methoxyphenyl)-2-(methylthio)thieno[3,2-b]thiophen-3-yl)-2,2-dimethylpropan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1125-25-3
S-methyl benzenethiosulfonate

: 1268375-47-8
1-(6-(4-methoxyphenyl)thieno[3,2-b]thiophen-3-yl)-2,2-dimethylpropan-1-one

: 1268375-57-0
1-(6-(4-methoxyphenyl)-2-(methylthio)thieno[3,2-b]thiophen-3-yl)-2,2-dimethylpropan-1-one

Guidance literature:: 1-(6-(4-methoxyphenyl)thieno[3,2-b]thiophen-3-yl)-2,2-dimethylpropan-1-one; With 2,2,6,6-tetramethylpiperidinyl magnesium chloride-lithium chloride; In tetrahydrofuran; at -50 ℃; Inert atmosphere;

S-methyl benzenethiosulfonate; In tetrahydrofuran; at -50 - 20 ℃; for 1h; regioselective reaction; Inert atmosphere;
DOI:10.1002/chem.201002506

Reference yield:

: 251-41-2
thieno[3,2-b]thiophene

: 1268375-57-0
1-(6-(4-methoxyphenyl)-2-(methylthio)thieno[3,2-b]thiophen-3-yl)-2,2-dimethylpropan-1-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 6 h / 20 °C / Inert atmosphere

2.1: 2,2,6,6-tetramethylpiperidinyl magnesium chloride-lithium chloride / tetrahydrofuran / 25 °C / Inert atmosphere

2.2: 0.25 h / 25 °C / Inert atmosphere

2.3: 4 h / 25 °C / Inert atmosphere

3.1: 2,2,6,6-tetramethylpiperidinyl magnesium chloride-lithium chloride / tetrahydrofuran / 25 °C / Inert atmosphere

3.2: 0.25 h / Inert atmosphere

3.3: 3 h / -20 - 20 °C / Inert atmosphere

4.1: palladium 10% on activated carbon; ammonium formate / ethanol; water / 5 h / 120 °C / Inert atmosphere; Microwave irradiation

5.1: 2,2,6,6-tetramethylpiperidinyl magnesium chloride-lithium chloride / tetrahydrofuran / -50 °C / Inert atmosphere

5.2: 1 h / -50 - 20 °C / Inert atmosphere

With N-chloro-succinimide; palladium 10% on activated carbon; 2,2,6,6-tetramethylpiperidinyl magnesium chloride-lithium chloride; ammonium formate; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1002/chem.201002506

Reference yield:

: 1268375-11-6
2,5-dichloro-3-(4-methoxyphenyl)thieno[3,2-b]thiophene

: 1268375-57-0
1-(6-(4-methoxyphenyl)-2-(methylthio)thieno[3,2-b]thiophen-3-yl)-2,2-dimethylpropan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,2,6,6-tetramethylpiperidinyl magnesium chloride-lithium chloride / tetrahydrofuran / 25 °C / Inert atmosphere

1.2: 0.25 h / Inert atmosphere

1.3: 3 h / -20 - 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; ammonium formate / ethanol; water / 5 h / 120 °C / Inert atmosphere; Microwave irradiation

3.1: 2,2,6,6-tetramethylpiperidinyl magnesium chloride-lithium chloride / tetrahydrofuran / -50 °C / Inert atmosphere

3.2: 1 h / -50 - 20 °C / Inert atmosphere

With palladium 10% on activated carbon; 2,2,6,6-tetramethylpiperidinyl magnesium chloride-lithium chloride; ammonium formate; In tetrahydrofuran; ethanol; water;
DOI:10.1002/chem.201002506