2-amino-2-hydroxymethyl-4-(4-octyl-phenyl)-butyric acid

Base Information

Chemical Name:2-amino-2-hydroxymethyl-4-(4-octyl-phenyl)-butyric acid
CAS No.:296282-46-7
Molecular Formula:C₁₉H₃₁NO₃
Molecular Weight:321.46
Hs Code.:

Synonyms:2-amino-2-hydroxymethyl-4-(4-octyl-phenyl)-butyric acid

Suppliers and Price of 2-amino-2-hydroxymethyl-4-(4-octyl-phenyl)-butyric acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 6 raw suppliers

Chemical Property of 2-amino-2-hydroxymethyl-4-(4-octyl-phenyl)-butyric acid

Chemical Property:

Purity/Quality:: > 95% ^*data from raw suppliers

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Technology Process of 2-amino-2-hydroxymethyl-4-(4-octyl-phenyl)-butyric acid

There total 9 articles about 2-amino-2-hydroxymethyl-4-(4-octyl-phenyl)-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 296282-78-5
N-[1-cyano-1-hydroxymethyl-3-(4-octylphenyl)propyl]acetamide

: 296282-46-7
2-amino-2-hydroxymethyl-4-(4-octyl-phenyl)-butyric acid

Guidance literature:: With hydrogenchloride; acetic acid; for 7h; Heating;
DOI:10.1021/jm000173z

Reference yield:

: 111-64-8
n-octanoic acid chloride

: 296282-46-7
2-amino-2-hydroxymethyl-4-(4-octyl-phenyl)-butyric acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: 43 percent / AlCl₃ / 1,2-dichloro-ethane / 3 h / 20 °C

2.1: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C

3.1: 3.40 g / NaOMe; MeOH / 2 h / Heating

4.1: Et₃N / CH₂Cl₂ / 1 h / 20 °C

5.1: 16.0 g / NaI / butan-2-one / 2 h / Heating

6.1: sodium ethoxide / ethanol / 0.5 h / 20 °C

6.2: 75 percent / ethanol / 3 h / 65 °C

7.1: 54 percent / LiBH₄ / tetrahydrofuran / 6 h / Heating

8.1: 66 percent / aq. HCl; AcOH / 7 h / Heating

With hydrogenchloride; methanol; triethylsilane; lithium borohydride; aluminium trichloride; sodium methylate; sodium ethanolate; acetic acid; triethylamine; trifluoroacetic acid; sodium iodide; In tetrahydrofuran; ethanol; dichloromethane; 1,2-dichloro-ethane; butanone; 1.1: Friedel-Crafts acylation / 2.1: Reduction / 3.1: Hydrolysis / 4.1: mesylation / 5.1: Iodination / 6.1: Metallation / 6.2: Alkylation / 7.1: Reduction / 8.1: Hydrolysis;
DOI:10.1021/jm000173z

Reference yield:

: 103-45-7
acetic acid phenethyl ester

: 296282-46-7
2-amino-2-hydroxymethyl-4-(4-octyl-phenyl)-butyric acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: 43 percent / AlCl₃ / 1,2-dichloro-ethane / 3 h / 20 °C

2.1: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C

3.1: 3.40 g / NaOMe; MeOH / 2 h / Heating

4.1: Et₃N / CH₂Cl₂ / 1 h / 20 °C

5.1: 16.0 g / NaI / butan-2-one / 2 h / Heating

6.1: sodium ethoxide / ethanol / 0.5 h / 20 °C

6.2: 75 percent / ethanol / 3 h / 65 °C

7.1: 54 percent / LiBH₄ / tetrahydrofuran / 6 h / Heating

8.1: 66 percent / aq. HCl; AcOH / 7 h / Heating

With hydrogenchloride; methanol; triethylsilane; lithium borohydride; aluminium trichloride; sodium methylate; sodium ethanolate; acetic acid; triethylamine; trifluoroacetic acid; sodium iodide; In tetrahydrofuran; ethanol; dichloromethane; 1,2-dichloro-ethane; butanone; 1.1: Friedel-Crafts acylation / 2.1: Reduction / 3.1: Hydrolysis / 4.1: mesylation / 5.1: Iodination / 6.1: Metallation / 6.2: Alkylation / 7.1: Reduction / 8.1: Hydrolysis;
DOI:10.1021/jm000173z