N-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)-N-(prop-2-ynyl)-1,4-dioxaspiro[4.5]decan-8-amine

Base Information

• Chemical Name: N-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)-N-(prop-2-ynyl)-1,4-dioxaspiro[4.5]decan-8-amine
• CAS No.: 1026083-88-4
• Molecular Formula: C₂₃H₃₁Cl₂N₃O₂
• Molecular Weight: 452.424

Synonyms:N-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)-N-(prop-2-ynyl)-1,4-dioxaspiro[4.5]decan-8-amine

Chemical Property of N-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)-N-(prop-2-ynyl)-1,4-dioxaspiro[4.5]decan-8-amine

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Technology Process of N-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)-N-(prop-2-ynyl)-1,4-dioxaspiro[4.5]decan-8-amine

There total 1 articles about N-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)-N-(prop-2-ynyl)-1,4-dioxaspiro[4.5]decan-8-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

N-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)-1,4-dioxaspiro[4.5]decan-8-amine (1026083-79-3) + propargyl bromide (106-96-7) → N-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)-N-(prop-2-ynyl)-1,4-dioxaspiro[4.5]decan-8-amine (1026083-88-4)

Guidance literature:

N-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)-1,4-dioxaspiro[4.5]decan-8-amine; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

propargyl bromide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; mineral oil; at 60 ℃; for 3h; Inert atmosphere;

DOI:10.1021/jm701524h

Reference yield: 73.0%

N-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)-N-(prop-2-ynyl)-1,4-dioxaspiro[4.5]decan-8-amine (1026083-88-4) → 4-((2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)(prop-2-ynyl)amino)cyclohexanone (1026083-98-6)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; at 80 ℃; for 6h; Inert atmosphere;

DOI:10.1021/jm701524h

upstream raw materials:

N-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)-1,4-dioxaspiro[4.5]decan-8-amine

propargyl bromide

Downstream raw materials:

4-((2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)(prop-2-ynyl)amino)cyclohexanone

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