N-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)-1,4-dioxaspiro[4.5]decan-8-amine

Base Information

Chemical Name:N-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)-1,4-dioxaspiro[4.5]decan-8-amine
CAS No.:1026083-79-3
Molecular Formula:C₂₀H₂₉Cl₂N₃O₂
Molecular Weight:414.375
Hs Code.:

Synonyms:N-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)-1,4-dioxaspiro[4.5]decan-8-amine

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Chemical Property of N-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)-1,4-dioxaspiro[4.5]decan-8-amine

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Technology Process of N-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)-1,4-dioxaspiro[4.5]decan-8-amine

There total 1 articles about N-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)-1,4-dioxaspiro[4.5]decan-8-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 4746-97-8
cyclohexanedione monoethylene ketal

: 163620-93-7
2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethanamine

: 1026083-79-3
N-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)-1,4-dioxaspiro[4.5]decan-8-amine

Guidance literature:: cyclohexanedione monoethylene ketal; 2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethanamine; With acetic acid; In 1,2-dichloro-ethane; at 0 ℃; for 0.5h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 8h; Inert atmosphere;
DOI:10.1021/jm701524h

Reference yield: 45.0%

: 1026083-79-3
N-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)-1,4-dioxaspiro[4.5]decan-8-amine

: 106-94-5
propyl bromide

: 1026083-82-8
N-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)-N-propyl-1,4-dioxaspiro[4.5]decan-8-amine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 10h;
DOI:10.1021/jm701524h

Reference yield: 39.0%

: 1026083-79-3
N-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)-1,4-dioxaspiro[4.5]decan-8-amine

: 106-96-7
propargyl bromide

: 1026083-88-4
N-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)-N-(prop-2-ynyl)-1,4-dioxaspiro[4.5]decan-8-amine

Guidance literature:: N-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)-1,4-dioxaspiro[4.5]decan-8-amine; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

propargyl bromide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; mineral oil; at 60 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jm701524h