9-[methyl 3,5-bis-O-(2,4-dichlorobenzyl)-α-D-arabinofuranosid-2-yl]adenine

Base Information

Chemical Name:9-[methyl 3,5-bis-O-(2,4-dichlorobenzyl)-α-D-arabinofuranosid-2-yl]adenine
CAS No.:1312805-16-5
Molecular Formula:C₂₅H₂₃Cl₄N₅O₄
Molecular Weight:599.301
Hs Code.:

Synonyms:9-[methyl 3,5-bis-O-(2,4-dichlorobenzyl)-α-D-arabinofuranosid-2-yl]adenine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 9-[methyl 3,5-bis-O-(2,4-dichlorobenzyl)-α-D-arabinofuranosid-2-yl]adenine

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Technology Process of 9-[methyl 3,5-bis-O-(2,4-dichlorobenzyl)-α-D-arabinofuranosid-2-yl]adenine

There total 4 articles about 9-[methyl 3,5-bis-O-(2,4-dichlorobenzyl)-α-D-arabinofuranosid-2-yl]adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1312805-13-2
methyl 3,5-bis-O-(2,4-dichlorobenzyl)-2-O-(trifluoromethylsulfonyl)-α-D-ribofuranoside

: 66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9
adenine

: 1312805-16-5
9-[methyl 3,5-bis-O-(2,4-dichlorobenzyl)-α-D-arabinofuranosid-2-yl]adenine

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 5h; Inert atmosphere;
DOI:10.1055/s-0030-1259961

Reference yield:

: 163759-40-8
methyl 2,3,5-tris-O-(2,4-dichlorobenzyl)-β-D-ribofuranoside

: 1312805-16-5
9-[methyl 3,5-bis-O-(2,4-dichlorobenzyl)-α-D-arabinofuranosid-2-yl]adenine

Guidance literature:: Multi-step reaction with 3 steps

1: tin(IV) chloride / dichloromethane / 28 h / 0 °C / Inert atmosphere

2: pyridine / 1 h / -40 - 0 °C / Inert atmosphere

3: caesium carbonate / N,N-dimethyl-formamide / 5 h / 60 °C / Inert atmosphere

With pyridine; tin(IV) chloride; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-0030-1259961

Reference yield:

: 7473-45-2
1-O-methyl-D-ribofuranose

: 1312805-16-5
9-[methyl 3,5-bis-O-(2,4-dichlorobenzyl)-α-D-arabinofuranosid-2-yl]adenine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 13 h / 0 - 20 °C

2: tin(IV) chloride / dichloromethane / 28 h / 0 °C / Inert atmosphere

3: pyridine / 1 h / -40 - 0 °C / Inert atmosphere

4: caesium carbonate / N,N-dimethyl-formamide / 5 h / 60 °C / Inert atmosphere

With pyridine; tin(IV) chloride; sodium hydride; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1055/s-0030-1259961