163759-40-8

Upstream product

• 67-56-1 methanol 
• 50-69-1 D-ribose 
• 94-99-5 2,4-Dichlorobenzyl chloride 
• 7473-45-2 1-O-methyl-D-ribofuranose 
• 1824-96-0 methyl ribofuranoside 
• 532-20-7 D-Ribose 

Downstream Products

• 55073-81-9 3-[methyl α-D-arabinofuranosid-2-yl]adenine 
• 1312805-14-3 4-chloro-7-[methyl 3,5-bis-O-(2,4-dichlorobenzyl)-α-D-arabinofuranosid-2-yl]-7H-pyrrolo[2,3-d]pyrimidine 
• 1312805-16-5 9-[methyl 3,5-bis-O-(2,4-dichlorobenzyl)-α-D-arabinofuranosid-2-yl]adenine 
• 1312805-18-7 4-amino-7-[methyl 3,5-bis-O-(2,4-dichlorobenzyl)-α-D-arabinofuranosid-2-yl]-7H-pyrrolo[2,3-d]pyrimidine 
• 1312805-20-1 7-[methyl 3,5-bis-O-(2,4-dichlorobenzyl)-α-D-arabinofuranosid-2-yl]-4-methoxy-7H-pyrrolo[2,3-d]pyrimidine 
• 168427-88-1 1-[(2R,3R,4R,5R)-4-(2,4-Dichloro-benzyloxy)-5-(2,4-dichloro-benzyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 168427-71-2 9-<3',5'-Bis-O-(2,4-dichlorobenzyl)-β-D-ribofuranosyl>-6-methoxy-9H-purin 
• 182495-86-9 1-{(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-propoxy-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione 
• 168427-66-5 1-[(2R,3R,4R,5R)-4-(2,4-Dichloro-benzyloxy)-5-(2,4-dichloro-benzyloxymethyl)-3-isopropoxy-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 168427-65-4 1-[(2R,3R,4R,5R)-4-(2,4-Dichloro-benzyloxy)-5-(2,4-dichloro-benzyloxymethyl)-3-propoxy-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 168427-64-3 1-[(2R,3R,4R,5R)-4-(2,4-Dichloro-benzyloxy)-5-(2,4-dichloro-benzyloxymethyl)-3-methoxy-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 163759-42-0 Methyl-2-O-acetyl-3,5-bis-O-(2,4-dichlorobenzyl)-α-D-ribofuranosid 
• 168427-74-5 2'-O-(2-methoxyethyl)adenosine 
• 163759-49-7 2'-O-(2-methoxyethyl)-5-methyluridine 

Relevant academic research and scientific papers

Discovery of 2'-α-C-Methyl-2'-β-C-fluorouridine Phosphoramidate Prodrugs as Inhibitors of Hepatitis C Virus

2′-α-C-Methyl-2′-β-C-fluorouridine and its phosphoramidate prodrugs were synthesized and evaluated for their inhibitory activity against HCV. The structure?activity relationship analysis of the phosphoramidate moiety found that 17m, 17q, and 17r exhibit potent activities against HCV, with EC50 values of 1.82 ± 0.19, 0.88 ± 0.12, and 2.24 ± 0.22 μM, respectively. The docking study revealed that the recognition of the 2′-β-F by Arg158, 3′-OH by N291, and the Watson?Crick pairing with the template allowed 23 to form the in-line conformation necessary for its incorporation into the viral RNA chain.

An efficient approach for the synthesis of 1′-O-α-methyl pyrrolo[2,3-d]pyrimidine isonucleosides

A series of novel 1′-O-methyl isonucleosides were efficiently and stereoselectively synthesized with 1,2,3,5-tetra-O-acetyl-D-ribofuranose as the starting material. The key steps include regioselective and stereoselective deprotection of the 2,4-dichlorobenzyl group at C2, triflation, and substitution with appropriate nucleobases using cesium carbonate as the base. Removal of the residual 2,4-dichlorobenzyl groups and subsequent transformation afforded the title compounds in 30-37% overall yield. The products represent a new type of isonucleosides with 1-O-substitution. Georg Thieme Verlag Stuttgart New York.

Nucleoside derivatives for treating hepatitis C virus infection

Disclosed are compounds, compositions and methods for treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus.

Nucleoside compounds for treating viral infections

Disclosed are compounds, compositions and methods for treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus.

38. A new access to 2'-O-alkylated ribonucleosides and properties of 2'-O-alkylated oligoribonucleotides

A general access to 2'-O-alkylated ribonucleosides using the key intermediate 5 is presented. The incorporation of 2'-O-'ethyleneglycol'- and 2'-O-'glycerol'-substituted (i.e., 2'-O-(2-hydroxyethyl)- and 2'-O-(2,3-dihydroxypropyl)-substituted) ribonucleosides into oligonucleotides affords a new generation of oligonucleotides with high affinity for RNA, high specificity, and increased nuclease resistance.