(2R)-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(2-oxo-1,3-oxazolidin-3-yl)-phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]propanamide

Base Information

Chemical Name:(2R)-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(2-oxo-1,3-oxazolidin-3-yl)-phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]propanamide
CAS No.:1443763-68-5
Molecular Formula:C₃₁H₂₇FN₆O₄
Molecular Weight:566.592
Hs Code.:

Synonyms:(2R)-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(2-oxo-1,3-oxazolidin-3-yl)-phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]propanamide

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Chemical Property of (2R)-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(2-oxo-1,3-oxazolidin-3-yl)-phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]propanamide

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Technology Process of (2R)-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(2-oxo-1,3-oxazolidin-3-yl)-phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]propanamide

There total 11 articles about (2R)-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(2-oxo-1,3-oxazolidin-3-yl)-phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 34837-84-8
4-fluorobenzeneacetic acid methyl ester

: 1443763-68-5
(2R)-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(2-oxo-1,3-oxazolidin-3-yl)-phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 1 h / -78 - 0 °C

2.1: potassium hydroxide; water / ethanol / 4 h / 0 °C

3.1: ethyl acetate / Reflux

4.1: sodium hydrogencarbonate; HATU / dichloromethane; N,N-dimethyl-formamide / 16 h / 20 °C

With water; sodium hydrogencarbonate; HATU; potassium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1443764-03-1
3-(4-{[6-(4-aminophenyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino}-3-methoxyphenyl)-1,3-oxazolidin-2-one

: 150360-26-2
(2R)-2-(4-fluorophenyl)propanoic acid

: 1443763-68-5
(2R)-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(2-oxo-1,3-oxazolidin-3-yl)-phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]propanamide

Guidance literature:: With sodium hydrogencarbonate; HATU; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 50415-71-9
methyl 2-(4-fluorophenyl)propanoate

: 1443763-68-5
(2R)-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(2-oxo-1,3-oxazolidin-3-yl)-phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide; water / ethanol / 4 h / 0 °C

2: ethyl acetate / Reflux

3: sodium hydrogencarbonate; HATU / dichloromethane; N,N-dimethyl-formamide / 16 h / 20 °C

With water; sodium hydrogencarbonate; HATU; potassium hydroxide; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;