NORCODEINE HYDROCHLORIDE TRIHYDRATE--*DE A SCHEDULE

Base Information

• Chemical Name: NORCODEINE HYDROCHLORIDE TRIHYDRATE--*DE A SCHEDULE
• CAS No.: 14648-14-7
• Molecular Formula: C17H19 N O3 . Cl H
• Molecular Weight: 321.804
• Mol file: 14648-14-7.mol

Synonyms:Morphinan-6a-ol, 7,8-didehydro-4,5a-epoxy-3-methoxy-, hydrochloride(8CI); Norcodeine hydrochloride

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of NORCODEINE HYDROCHLORIDE TRIHYDRATE--*DE A SCHEDULE

Chemical Property:

• Melting Point: 1850C
• PSA: 50.72000
• LogP: 2.28970
• Storage Temp.: Controlled Substance, -20°C Freezer

Purity/Quality:

Safty Information:

• Pictogram(s): Xn,T,F
• Hazard Codes: Xn,T,F
• Statements: 20/21/22-39/23/24/25-23/24/25-11
• Safety Statements: 36/37/39-45-36/37-16-7

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A metabolite of Codeine. Morphine derivative.

Technology Process of NORCODEINE HYDROCHLORIDE TRIHYDRATE--*DE A SCHEDULE

There total 2 articles about NORCODEINE HYDROCHLORIDE TRIHYDRATE--*DE A SCHEDULE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

codeine N-oxide hydrochloride → N-norcodeine hydrochloride (14648-14-7) + codeine hydrochloride (1422-07-7)

Guidance literature:

With iron(III) chloride hexahydrate; iron; In chloroform; isopropyl alcohol; at 20 ℃; for 36h;

DOI:10.1071/CH11320

Reference yield:

codeine (76-57-3) → N-norcodeine hydrochloride (14648-14-7) + codeine hydrochloride (1422-07-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / chloroform; isopropyl alcohol / 0.42 h / -5 °C

2: iron(III) chloride hexahydrate; iron / chloroform; isopropyl alcohol / 36 h / 20 °C

With iron(III) chloride hexahydrate; iron; 3-chloro-benzenecarboperoxoic acid; In chloroform; isopropyl alcohol;

DOI:10.1071/CH11320

Reference yield:

N-norcodeine hydrochloride (14648-14-7) → norcodeine (467-15-2,10118-79-3,25318-90-5,131830-12-1)

Guidance literature:

With sodium hydroxide; In water;

DOI:10.1071/CH11320

upstream raw materials:

codeine

Downstream raw materials:

norcodeine